Skip to main content

Headache and Pain

Edited by: Professor Paolo Martelletti and Professor Maria Adele Giamberardino

The Headache and Pain Collection is a new venue for research in the field of headache disorders and pain and publishes original research on the impact, epidemiology, nature, mechanisms and treatment of all forms of headache and pain. The Collection provides a platform for the dissemination of research in the basic and clinical sciences from a multidisciplinary point of view.

Articles published in SpringerPlus: Headache and Pain Collection are linked to The Journal of Headache and Pain.

The Headache and Pain Collection is a sister title of The Journal of Headache and Pain, providing a new Open Access forum for publication of scientifically valuable manuscripts.

Click here to view all members of the collection's editorial board.

Subject matters for the sister Collection include (in humans and other animals):

  • epidemiology
  • public health
  • biochemistry
  • biomedicine
  • food science
  • immunology
  • physiology
  • pharmacology
  • toxicology
  • peptides
  • genetics

All manuscripts are subject to rigorous peer reviews for their suitability of publication in SpringerPlus.

As Editors in Chief of this Collection, we offer you a new platform, SpringerPlus: Headache and Pain Collection, as home of your research.

Submission Instructions

If your manuscript meets the aims and scope of this individual Collection, please first follow all of the SpringerPlus Submission Guidelines.

During submission, at the "Additional Information" section, please select that you are submitting to an Article Collection, and choose “Headache and Pain” from the list.

Collection Articles:

  1. Research

    Impact of headaches on university students in Durban, South Africa

    Introspection into the factors that affect student success at higher education institutions has gained significant momentum in recent years. Teaching and learning has come under the spotlight with quality enha...

    Jyotika Basdav, Firoza Haffejee and T. Puckree

    SpringerPlus 2016 5:1679

    Published on: 29 September 2016

  2. Research

    The psychometric properties of the Comprehensive Headache-related Quality of life Questionnaire (CHQQ) translated to Serbian

    The Comprehensive Headache-related Quality of life Questionnaire (CHQQ), is a recently developed and validated instrument, intended for measuring quality of life of patients with all headache types. Currently ...

    Slobodan M. Jankovic, Marija Andjelkovic, Radica Zivkovic Zaric, Marko Vasic, Éva Csépány, Tamás Gyüre and Csaba Ertsey

    SpringerPlus 2016 5:1416

    Published on: 24 August 2016

  3. Research

    Headache in Behcet’s disease: types and characteristics

    Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a pa...

    Maryam Moghaddassi, Mansoureh Togha, Farhad Shahram, Hamed Hanif, Sahar Dadkhah, Soodeh Razeghi Jahromi and Mohammad Mozafari

    SpringerPlus 2016 5:1077

    Published on: 13 July 2016

  4. Research

    Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients

    Patients suffering from migraine or tension-type headache (TTH) often treat their complaints with over-the-counter (OTC) medications. Fixed dose combinations of acetylsalicylic acid, paracetamol and caffeine (...

    Charly Gaul, Heidemarie Gräter and Thomas Weiser

    SpringerPlus 2016 5:721

    Published on: 14 June 2016

  5. Review

    Recent advances in migraine therapy

    Migraine is a common and highly disabling neurological disorder associated with a high socioeconomic burden. Effective migraine management depends on adequate patient education: to avoid unrealistic expectati...

    Fabio Antonaci, Natascia Ghiotto, Shizheng Wu, Ennio Pucci and Alfredo Costa

    SpringerPlus 2016 5:637

    Published on: 17 May 2016

  6. Research

    Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia

    BoNT-A is often used in the clinical treatment for movement disorders. In recent years, various clinical studies suggest that BoNT-A can effectively alleviate pain caused by trigeminal neuralgia (TN); however,...

    Chuanjie Wu, Nanchang Xie, Yajun Lian, Hongliang Xu, Chen Chen, Yake Zheng, Yuan Chen and Haifeng Zhang

    SpringerPlus 2016 5:431

    Published on: 11 April 2016

  7. Research

    Linear headache: clinical characteristics of eight new cases

    Linear headache (LH) has recently been described as a paroxysmal or continuous fixed head pain restricted in a linear trajectory of 5–10 mm in width, linking one endpoint in occipital or occipitocervical regio...

    Ya-Nan Lu, Qing-Qing Pan, Jie-Feng Pan, Lei Wang, Yun-Yun Lu, Liang-Hui Hu and Yu Wang

    SpringerPlus 2016 5:347

    Published on: 18 March 2016

  8. Research

    Efficacy of epidural blood patch with fibrin glue additive in refractory headache due to intracranial hypotension: preliminary report

    Injection of fibrin glue mixed with blood into the epidural space to reliably and effectively treat medically refractory orthostatic headache caused by spinal cerebrospinal fluid (CSF) leaks and subsequent int...

    Justin J. Elwood, Misha Dewan, Jolene M. Smith, Bahram Mokri, William D. Mauck and Jason S. Eldrige

    SpringerPlus 2016 5:317

    Published on: 11 March 2016

    The Erratum to this article has been published in SpringerPlus 2016 5:960

  9. Research

    “Pointing forehead”: a new physical sign in migraine

    This study was designed to compare the presence of seven clinical signs in a group of patients with migraine with that of patients with non-migraine headache. Migraine is sometimes misdiagnosed. Therefore addi...

    M. A. A. K. Munasinghe, Vajira Weerasinghe and M. A. S. C. Samarakoon

    SpringerPlus 2016 5:194

    Published on: 27 February 2016

  10. Research

    Coping strategies among adolescents with chronic headache and mental health problems: a cross-sectional population-based study

    To examine prevalence of mental health problems among adolescents with chronic headache and compare internal and external coping strategies in young people with chronic headaches with and without mental health...

    Silje Hartberg, Jocelyne Clench-Aas, Ruth Kjærsti Raanaas and Christofer Lundqvist

    SpringerPlus 2015 4:801

    Published on: 22 December 2015

  11. Short report

    Examination of fluctuations in atmospheric pressure related to migraine

    Japan has four seasons and many chances of low atmospheric pressure or approaches of typhoon, therefore it has been empirically known that the fluctuation of weather induces migraine in people. Generally, its ...

    Hirohisa Okuma, Yumiko Okuma and Yasuhisa Kitagawa

    SpringerPlus 2015 4:790

    Published on: 18 December 2015

  12. Case Study

    Use of botulinum toxin injections to treat peripheral stimulator induced facial muscle twitching: a case report

    Facial pain can be a management challenge. Peripheral nerve/field stimulation may be an effective option for refractory cases, but direct muscle stimulation with facial twitching may result. Botulinum toxin in...

    Terrence L. Trentman, Jillian A. Maloney, Christopher S. Wie, Alanna M. Rebecca and David M. Rosenfeld

    SpringerPlus 2015 4:671

    Published on: 4 November 2015

  13. Research

    Can atlas spina bifida-occulta be a cause of cervicogenic headaches?

    Cervicogenic headaches are a nosologic entity recently recognized. In our common practice, we have noticed a relative frequency of the atlas spina-bifida occulta during the brain CT scan realized for headaches...

    Amégninou Mawuko Yao Adigo, Lama Kegdigoma Agoda-Kousséma, Ignéza Komi Agbotsou, Kokou Adambounou, Kpalma Duga Bakpatina-Batako, Oni Djagnikpo and Komlanvi Victor Adjénou

    SpringerPlus 2015 4:605

    Published on: 13 October 2015

  14. Research

    OnabotulinumtoxinA treatment for chronic migraine: experience in 52 patients treated with the PREEMPT paradigm

    OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) after publication of PREEMPT trials. Thus, we set out to evaluate the efficacy of OnabotA in a series of patients with CM treate...

    María Isabel Pedraza, Carolina de la Cruz, Marina Ruiz, Luis López-Mesonero, Elena Martínez, Mercedes de Lera and Ángel Luis Guerrero

    SpringerPlus 2015 4:176

    Published on: 13 April 2015

  15. Short report

    Status migrainosus as an initial presentation of multiple sclerosis

    Demyelinating plaques may induce headache through disruption of the pathways, which are implicated in the pathogeneses of migraine. We report a case of 25-year-old female patient, who presented with status mig...

    Raed Alroughani, Samar F Ahmed, Riyadh Khan and Jasem Al-Hashel

    SpringerPlus 2015 4:28

    Published on: 23 January 2015

  16. Case study

    Intracranial hypotension after trauma

    Intracranial hypotension (IH) occurs typically spontaneous and is a potentially life-threatening condition characterized by symptoms varying from postural headache to coma, with classical magnetic resonance im...

    Asita S Sarrafzadeh, Stephanie A Hopf, Oliver P Gautschi, Ana-Paula Narata and Karl Schaller

    SpringerPlus 2014 3:153

    Published on: 21 March 2014

  17. Review

    Symptomatic cluster headache: a review of 63 cases

    Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. Symptomatic cases have been described, for example tumours, dissections and infections, but a causa...

    Bengt Edvardsson

    SpringerPlus 2014 3:64

    Published on: 3 February 2014

  18. Case study

    Cortical non-aneurysmal subarachnoid hemorrhage post-carotid endarterectomy: a case report and literature review

    Cerebral hyperperfusion syndrome is a well-recognized and potentially fatal complication of carotid revascularization. However, the occurrence of non-aneurysmal subarachnoid hemorrhage as a manifestation of ce...

    Gopiga Thanabalasundaram, Silvia Hernández-Durán, Thabele Leslie-Mazwi and Christopher S Ogilvy

    SpringerPlus 2013 2:571

    Published on: 29 October 2013

  19. Case study

    Cluster headache associated with acute maxillary sinusitis

    Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described, for example tumours, particularly pituitary adenoma...

    Bengt Edvardsson

    SpringerPlus 2013 2:509

    Published on: 5 October 2013

  20. Letter to the Editor

    A computerized expert system for diagnosing primary headache based on International Classification of Headache Disorder (ICHD-II)

    The authors developed a computerized program designed to diagnose primary headache based on international classification of headache disorders, 2nd edition (ICHD-II) criteria for use by physicians.

    Vahid Eslami, Sadreddin Rouhani-Esfahani, Nima Hafezi-Nejad, Farshid Refaeian, Siamak Abdi and Mansoureh Togha

    SpringerPlus 2013 2:199

    Published on: 30 April 2013

  21. Research

    Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

    In a recent meta-analysis migraine was associated with a two-fold increase in stroke risk. While the mechanism driving this association is unknown, one intriguing hypothesis is that migraineurs are genetically...

    Andrea M Harriott, Nicole Dueker, Yu-Ching Cheng, Kathleen A Ryan, Jeffrey R O’Connell, O Colin Stine, Patrick F McArdle, Marcella A Wozniak, Barney J Stern, Braxton D Mitchell, Steven J Kittner and John W Cole

    SpringerPlus 2013 2:46

    Published on: 11 February 2013

  22. Case study

    Headache after exposure to ‘date-rape’ drugs

    We report two patients who developed a prolonged featureless headache, they think after a drink was ‘spiked’. We speculate that each was exposed to scopolamine, resulting in enhanced trigeminal release of vaso...

    Richard Peatfield and Carlos M Villalón

    SpringerPlus 2013 2:39

    Published on: 8 February 2013

  23. Case study

    Cluster headache and arachnoid cyst

    Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described, e.g. tumours, particularly pituitary adenomas, malf...

    Bengt Edvardsson and Staffan Persson

    SpringerPlus 2013 2:4

    Published on: 10 January 2013

  24. Letter to the Editor

    Triggers of migraine in children at a public hospital in India

    We conducted a descriptive study of children presenting with recurrent headaches to the general pediatric services of a tertiary-care, public hospital in northern India. This paper reports on the triggering fa...

    Devendra Mishra and Ankit Sharma

    SpringerPlus 2012 1:45

    Published on: 30 October 2012