Brain metabolism, neuropathology and neurodegeneration

Edited by:

Matteo Bauckneht, PhD, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Guido Rovera, M.D.,University of Turin, Italy

Submission Status: Open | Submission Deadline: 23 June 2025

This Collection invites researchers to contribute original studies and reviews that explore the interplay between brain metabolism, neuropathology, and neurodegeneration. We welcome submissions that utilize advanced imaging techniques, such as PET, to investigate metabolic alterations and their implications for neurodegenerative diseases. The goal is to enhance our understanding of these complex interactions and to inform the development of innovative diagnostic and therapeutic strategies.

New Content Item This collection supports and amplifies research related to SDG 3: (Good Health and Well-being)

About the Collection

The intricate relationship between brain metabolism, neuropathology, and neurodegeneration is a critical area of research that seeks to unravel the complexities of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and other forms of dementia. Understanding how metabolic processes in the brain are altered in these conditions can provide insights into the underlying mechanisms of disease progression and pathology. Advances in imaging techniques, particularly positron emission tomography (PET), have enabled researchers to visualize metabolic changes and neuroinflammation in vivo, paving the way for a deeper understanding of the biochemical landscape of neurodegeneration.

Continuing to advance our collective understanding in this area is essential for developing effective therapeutic strategies and diagnostic tools. Recent breakthroughs in amyloid imaging and glucose metabolism studies have significantly enhanced our ability to detect early pathological changes in the brain, allowing for timely interventions. Furthermore, research into neuroinflammation has opened new avenues for potential treatments, highlighting the importance of targeting inflammatory processes in neurodegenerative diseases.

As research progresses, we may witness the emergence of novel biomarkers that can predict disease onset and progression more accurately. Additionally, advancements in personalized medicine could lead to tailored therapeutic approaches that address the unique metabolic profiles of individuals with neurodegenerative diseases. The integration of multi-modal imaging techniques and machine learning algorithms may also enhance our understanding of brain metabolism and its role in neuropathology, ultimately leading to improved patient outcomes. Article topics of interest for this collection include, but are not limited to:

Brain metabolism in neurodegeneration
PET imaging of neuroinflammation
Amyloid imaging in Alzheimer's disease
Glucose metabolism and cognitive decline
Neuropathological changes in neurodegenerative diseases

Submission Guidelines

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This Collection welcomes submission of Research Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system. During the submission process, under the section additional information, you will be asked whether you are submitting to a Collection, please select "Brain metabolism, neuropathology and neurodegeneration" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.

There are currently no articles in this collection.