Chemistry of ageing
Gerontology has traditionally been dominated by biological research groups. In recent years, the potential impact of chemical analysis and small molecule interventions has become widely recognised, and there are now a growing number of chemists undertaking ageing research. Research into ageing spans the full range chemistry. Advanced analytical and physical techniques are being used to observe age-related changes in living organisms. Equally, novel synthetic and medicinal chemistry is generating small molecule tools for the dissection of complex biological pathways, as well as potential life- and health-span extending therapeutics.
This thematic issue on the chemistry of ageing covers topics such as: glycation, oxidative stress and other degenerative processes; cellular senescence, mechanistic dissection and interventions; telomerase inhibitors and activators; small molecules with life-extending activity such as resveratrol and rapamycin; and novel methods for mining complex cohort and life-course data.
Editor: Dr Elizabeth Ostler