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Chemistry of ageing


Gerontology has traditionally been dominated by biological research groups. In recent years, the potential impact of chemical analysis and small molecule interventions has become widely recognised, and there are now a growing number of chemists undertaking ageing research. Research into ageing spans the full range chemistry. Advanced analytical and physical techniques are being used to observe age-related changes in living organisms. Equally, novel synthetic and medicinal chemistry is generating small molecule tools for the dissection of complex biological pathways, as well as potential life- and health-span extending therapeutics.

This thematic issue on the chemistry of ageing covers topics such as: glycation, oxidative stress and other degenerative processes; cellular senescence, mechanistic dissection and interventions; telomerase inhibitors and activators; small molecules with life-extending activity such as resveratrol and rapamycin; and novel methods for mining complex cohort and life-course data.

Editor: Dr Elizabeth Ostler


  1. Review

    Chemical consequences of cutaneous photoageing

    Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In part...

    Sarah A Thurstan, Neil K Gibbs, Abigail K Langton, Christopher EM Griffiths, Rachel EB Watson and Michael J Sherratt

    Chemistry Central Journal 2012 6:34

    Published on: 25 April 2012

  2. Preliminary communication

    Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors

    Fibroblasts derived from the progeroid Werner syndrome show reduced replicative lifespan and a "stressed" morphology, both alleviated using the MAP kinase inhibitor SB203580. However, interpretation of these d...

    Terence Davis, Matthew C Dix, Michal J Rokicki, Amy JC Brook, Caroline S Widdowson, David Kipling and Mark C Bagley

    Chemistry Central Journal 2011 5:83

    Published on: 8 December 2011