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Chemistry of ageing 2013

Gerontology has traditionally been dominated by biological research groups. In recent years, the potential impact of chemical analysis and small molecule interventions has become widely recognised, and there are now a growing number of chemists undertaking ageing research. Research into ageing spans the full range chemistry. Advanced analytical and physical techniques are being used to observe age-related changes in living organisms. Equally, novel synthetic and medicinal chemistry is generating small molecule tools for the dissection of complex biological pathways, as well as potential life- and health-span extending therapeutics.

This thematic series follows on from a series of papers on the chemistry of ageing published in 2012.

  1. Research article

    Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion

    During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione depletion and metabolic stress. Maintaining redox homeostasis is impo...

    Rita Barreto Duarte Carilho Torrao, Irundika HK Dias, Stuart J Bennett, Christopher R Dunston and Helen R Griffiths

    Chemistry Central Journal 2013 7:150

    Published on: 5 September 2013

  2. Review

    Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?

    The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on cellular activity. It delays cellular senescence and rejuvenates cultured senescent mammalian cells. However, it also in...

    Alan R Hipkiss, Stephanie P Cartwright, Clare Bromley, Stephane R Gross and Roslyn M Bill

    Chemistry Central Journal 2013 7:38

    Published on: 25 February 2013

  3. Preliminary communication

    The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

    Fibroblasts derived from the progeroid Werner syndrome (WS) show reduced replicative lifespan and a “stressed” morphology, both phenotypes being alleviated by using the p38 MAP kinase inhibitor SB203580. Becau...

    Terence Davis, Michal J Rokicki, Mark C Bagley and David Kipling

    Chemistry Central Journal 2013 7:18

    Published on: 29 January 2013