Skip to main content

Structural chemistry of small molecules of biological interest


The results from crystallographic studies of small molecules of biological interest have enriched the knowledgebase widely used in various areas of molecular sciences. This includes, but is not limited to, understanding biomacromolecular interactions, crystal and molecular engineering, structure based drug design, computational chemistry and molecular modelling, and the design of novel functional materials.

Editors: Dr Simon Coles, Prof Packianathan Thomas Muthiah


  1. Research article

    Solid-phase molecular recognition of cytosine based on proton-transfer reaction. Part II. supramolecular architecture in the cocrystals of cytosine and its 5-Fluoroderivative with 5-Nitrouracil

    Cytosine is a biologically important compound owing to its natural occurrence as a component of nucleic acids. Cytosine plays a crucial role in DNA/RNA base pairing, through several hydrogen-bonding patterns, ...

    Gustavo Portalone

    Chemistry Central Journal 2011 5:51

    Published on: 2 September 2011

  2. Research article

    Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives

    The spiro- indole-pyrrolidine ring system is a frequently encountered structural motif in many biologically important and pharmacologically relevant alkaloids. The derivatives of spirooxindole ring systems are...

    Jeyaperumal Kalyana Sundar, Stephen Michael Rajesh, Jeyaraman Sivamani, Subbu Perumal and Subramanian Natarajan

    Chemistry Central Journal 2011 5:45

    Published on: 26 July 2011