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Computational Systems Biology 2010

  1. Content type: Research

    In recent years, cell population models have become increasingly common. In contrast to classic single cell models, population models allow for the study of cell-to-cell variability, a crucial phenomenon in mo...

    Authors: Jan Hasenauer, Julian Heinrich, Malgorzata Doszczak, Peter Scheurich, Daniel Weiskopf and Frank Allgöwer

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:4

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  2. Content type: Research

    The identification of molecular target and mechanism of action of compounds is a key hurdle in drug discovery. Multiplexed techniques for bead-based expression profiling allow the measurement of transcriptiona...

    Authors: Florian Nigsch, Janna Hutz, Ben Cornett, Douglas W Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro and Jeremy L Jenkins

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:2

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  3. Content type: Research

    Boolean models of regulatory networks are assumed to be tolerant to perturbations. That qualitatively implies that each function can only depend on a few nodes. Biologically motivated constraints further show ...

    Authors: Steffen Schober, David Kracht, Reinhard Heckel and Martin Bossert

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:6

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  4. Content type: Research

    In systems biology, experimentally measured parameters are not always available, necessitating the use of computationally based parameter estimation. In order to rely on estimated parameters, it is critical to...

    Authors: Syed Murtuza Baker, C Hart Poskar and Björn H Junker

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:7

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  5. Content type: Research

    Proteins and their interactions are essential for the survival of each human cell. Knowledge of their tissue occurrence is important for understanding biological processes. Therefore, we analyzed microarray an...

    Authors: Dorothea Emig, Tim Kacprowski and Mario Albrecht

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:5

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  6. Content type: Research

    Plant carbohydrate metabolism comprises numerous metabolite interconversions, some of which form cycles of metabolite degradation and re-synthesis and are thus referred to as futile cycles. In this study, we p...

    Authors: Sebastian Henkel, Thomas Nägele, Imke Hörmiller, Thomas Sauter, Oliver Sawodny, Michael Ederer and Arnd G Heyer

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:2

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  7. Content type: Research

    Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFκB activation caused by continuous IKKβ phosphorylation. We have recently published a strictly reduced ordinary...

    Authors: Johannes Witt, Sandra Barisic, Oliver Sawodny, Michael Ederer, Dagmar Kulms and Thomas Sauter

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:3

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  8. Content type: Research

    Elucidating the structure and/or dynamics of gene regulatory networks from experimental data is a major goal of systems biology. Stochastic models have the potential to absorb noise, account for un-certainty, ...

    Authors: Elena S Dimitrova, Indranil Mitra and Abdul Salam Jarrah

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:1

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