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Blood purification in sepsis: from bench to bedside

Edited by:
Dr. Klaus Stahl, MD, Hannover Medical School, Germany

Submission Status: Open   |   Submission Deadline: Ongoing 


Intensive Care Medicine Experimental is calling for submissions to the new topical collection on blood purification in sepsis. The idea of extracorporeal blood purification (aside from classical renal replacement therapy) to eliminate injurious mediators of the sepsis syndrome has received increasing interest over the last years. In fact, blood purification techniques, such as hemoadsorption, are already widely used in clinical practice due to its plausible theoretical rationale, despite lack of clear evidence. Moreover, some recent studies have raised important risk-benefit concerns underlining the fundamental need of further research in this field. This thematic collection invites authors to focus on both pre-clinical and clinical approaches to explore future perspectives of blood purification in the additive treatment of sepsis. The aim is not only to contribute to an improved understanding of the molecular mechanisms influenced by blood purification but also to set the stage for taking the next steps to improve the clinical management.

Guest Editors

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Klaus Stahl, MD, Hannover Medical School, Germany

Klaus Stahl is a nephrologist, gastroenterologist and intensivist at Hannover Medical School in Germany. He is interested in clinical and translational research in septic shock, ARDS and liver failure. A special focus of his research lies on extracorporeal treatment modalities such as therapeutic plasma exchange in septic shock and ECMO in ARDS. As PI of the EXCHANGE study program, he has explored use of therapeutic plasma exchange in refractory septic shock in both clinical trials as well as translational experiments. As a co-founder of the BonHanZA study group he is excited to tackle a broad range of novel questions in critical care medicine.

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system. During the submission process, under the section additional information, you will be asked whether you are submitting to a Collection, please select "Blood purification in sepsis: from bench to bedside" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.

  1. IL-6 is a pleiotropic cytokine modulating inflammation and metabolic pathways. Its proinflammatory effect plays a significant role in organ failure pathogenesis, commonly elevated in systemic inflammatory cond...

    Authors: Susanne Himmelein, Aritz Perez Ruiz de Garibay, Veronika Brandel, Frank Zierfuß and Tobias Michael Bingold
    Citation: Intensive Care Medicine Experimental 2024 12:66
    Content type: Research Articles Published on:

  2. Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis a...

    Authors: Klaus Stahl, Christian Bode, Benjamin Seeliger, Pedro David Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2024 12:5
    Content type: Research Articles Published on:

  4. Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the la...

    Authors: Sascha David, Lene Russell, Pedro Castro, Andry van de Louw, Lara Zafrani, Tasneem Pirani, Nathan D. Nielsen, Eric Mariotte, Bruno L. Ferreyro, Jan T. Kielstein, Luca Montini, Anne C. Brignier, Matthias Kochanek, Joan Cid, Chiara Robba, Ignacio Martin-Loeches…
    Citation: Intensive Care Medicine Experimental 2023 11:26
    Content type: Reviews Published on:

  5. Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozon...

    Authors: Paul Skorup, Anette Fransson, Jenny Gustavsson, Johan Sjöholm, Henrik Rundgren, Volkan Özenci, Alicia Y. W. Wong, Tomas Karlsson, Christer Svensén and Mattias Günther
    Citation: Intensive Care Medicine Experimental 2022 10:14
    Content type: Research Articles Published on:

  6. Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co...

    Authors: Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller and Sascha David
    Citation: Intensive Care Medicine Experimental 2021 9:57
    Content type: Research Articles Published on:

  7. Platelet–neutrophil complexes (PNCs) readily migrate into tissues and induce tissue damage via cytokine or other pathogenic factors release. These actions are involved in onset and progression of acute respira...

    Authors: Yumiko Sekiya, Kaoru Shimada, Hiroshi Takahashi, Chisa Kuga, Shunsuke Komachi, Keishi Miwa and Toru Kotani
    Citation: Intensive Care Medicine Experimental 2021 9:49
    Content type: Research Articles Published on:

  10. Mounting evidence suggests that sepsis-induced morbidity and mortality are due to both immune activation and immunosuppression. Resistin is an inflammatory cytokine and uremic toxin. Septic hyperresistinemia (...

    Authors: Anthony Bonavia, Lauren Miller, John A. Kellum and Kai Singbartl
    Citation: Intensive Care Medicine Experimental 2017 5:36
    Content type: Research Published on:

  11. Novel extracorporeal procedures are constantly being developed and evaluated for use in patients with sepsis. Preclinical evaluation of such procedures usually requires testing in large animal models. In the p...

    Authors: Ahmed Al-Chalabi, Edouard Matevossian, Anne von Thaden, Catherine Schreiber, Peter Radermacher, Wolfgang Huber, Aritz Perez Ruiz de Garibay and Bernhard Kreymann
    Citation: Intensive Care Medicine Experimental 2017 5:31
    Content type: Research Published on: