Gaseous Mediators: Potential application in Critical Care

H₂S in acute lung injury: a therapeutic dead end(?)

This review addresses the plausibility of hydrogen sulfide (H₂S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The re...

Authors: Tamara Merz, Nicole Denoix, Martin Wepler, Holger Gäßler, David A. C. Messerer, Clair Hartmann, Thomas Datzmann, Peter Radermacher and Oscar McCook

Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):33

Content type: Review Published on: 18 December 2020

This article is part of a Supplement: Volume 8 Supplement 1
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Update of the organoprotective properties of xenon and argon: from bench to beside

The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients receiving treatment for ST-segment-...

Authors: Roehl Anna, Rossaint Rolf and Coburn Mark

Citation: Intensive Care Medicine Experimental 2020 8:11

Content type: Review Published on: 24 February 2020
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Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Hydrogen sulfide (H₂S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H₂S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological...

Authors: Eizo Marutani and Fumito Ichinose

Citation: Intensive Care Medicine Experimental 2020 8:5

Content type: Review Published on: 31 January 2020
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Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resul...

Authors: Ulrich Goebel and Jakob Wollborn

Citation: Intensive Care Medicine Experimental 2020 8:2

Content type: Review Published on: 9 January 2020
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Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble...

Authors: Nina C. Weber and Benedikt Preckel

Citation: Intensive Care Medicine Experimental 2019 7:73

Content type: Review Published on: 19 December 2019
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Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi...

Authors: Mathun Kuganesan, Kavitej Samra, Eloise Evans, Mervyn Singer and Alex Dyson

Citation: Intensive Care Medicine Experimental 2019 7:71

Content type: Review Published on: 16 December 2019
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Methane and Inflammation - A Review (Fight Fire with Fire)

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co...

Authors: Marietta Zita Poles, László Juhász and Mihály Boros

Citation: Intensive Care Medicine Experimental 2019 7:68

Content type: Review Published on: 5 December 2019
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Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update

Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r...

Authors: Simon Lambden

Citation: Intensive Care Medicine Experimental 2019 7:64

Content type: Review Published on: 2 December 2019
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