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Pituitary adenylate cyclase activating peptide (PACAP) - an emerging molecule in primary headaches

Edited by: Messoud Ashina

Here, we introduce the The Journal of Headache and Pain thematic series on pituitary adenylate cyclase activating peptide (PACAP) as an emerging molecule in primary headaches. Over the past decade PACAP has emerged as a key signaling in migraine and cluster headache and this thematic series summarizes the most important aspects of PACAP physiological functions from its discovery in the central nervous system to experimental studies with relevance to primary headaches.

This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief and Guest Editor. The Editor-in-Chief and Guest Editor declare no competing interests.

  1. Content type: Review article

    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

    Authors: Faisal Mohammad Amin and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2018 19:35

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  2. Content type: Review article

    Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

    Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

    Citation: The Journal of Headache and Pain 2018 19:28

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  3. Content type: Review article

    The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

    Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

    Citation: The Journal of Headache and Pain 2018 19:23

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  4. Content type: Review article

    Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    Citation: The Journal of Headache and Pain 2018 19:21

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  5. Content type: Review article

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

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  6. Content type: Review article

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

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  7. Content type: Review article

    To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

    Authors: Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:110

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