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Breast Cancer

Edited by: Dr Marc Lippman

The Breast Cancer Collection is an invitation-only sister title of the Springer subscription journal, Breast Cancer Research and Treatment (BREA).

Invited submissions should choose the Breast Cancer Collection during submission, and include the invitation letter from Dr Lippman in their SpringerPlus cover letter.

For more information about how you can be considered for the Breast Cancer Collection, please speak to the editorial team at BREA.


Collection Articles:

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  1. Research

    Safety and tolerability of etirinotecan pegol in advanced breast cancer: analysis of the randomized, phase 3 BEACON trial

    New treatments with novel mechanisms of action and non-overlapping toxicities are needed for patients with metastatic breast cancer. Etirinotecan pegol (EP) is a long-acting topoisomerase-I inhibitor with a un...

    Javier Cortés, Hope S. Rugo, Chris Twelves, Ahmad Awada, Edith A. Perez, Seock-Ah Im, Carol Zhao, Ute Hoch, Denise Tomkinson, James Buchanan, Mary Tagliaferri, Alison Hannah and Joyce O’Shaughnessy

    SpringerPlus 2016 5:1033

    Published on: 8 July 2016

  2. Research

    Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice

    To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases det...

    Peter Rusch, Oliver Hoffmann, Anna-L. Stickelmann, Stephan Böhmer, Regine Gätje, Karl G. Krüger, Stefan Niesert, Andrea Schmidt and Rainer Kimmig

    SpringerPlus 2016 5:1010

    Published on: 7 July 2016

  3. Research

    Breast reconstruction after mastectomy at a comprehensive cancer center

    Breast reconstruction after mastectomy is an integral part of breast cancer treatment that positively impacts quality of life in breast cancer survivors. Although breast reconstruction rates have increased ove...

    Shahnjayla K. Connors, Melody S. Goodman, Terence Myckatyn, Julie Margenthaler and Sarah Gehlert

    SpringerPlus 2016 5:955

    Published on: 2 July 2016

  4. Research

    A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer

    Glucocorticoid receptor (GR) overexpression is associated with poor prognosis ER-negative breast cancer. GR antagonism with mifepristone increases chemotherapy-induced breast cancer cell death, therefore we co...

    Rita Nanda, Erica M. Stringer-Reasor, Poornima Saha, Masha Kocherginsky, Jean Gibson, Bernadette Libao, Philip C. Hoffman, Elias Obeid, Douglas E. Merkel, Galina Khramtsova, Maxwell Skor, Thomas Krausz, Ronald N. Cohen, Mark J. Ratain, Gini F. Fleming and Suzanne D. Conzen

    SpringerPlus 2016 5:947

    Published on: 30 June 2016

  5. Research

    Detection of a numeric value predictive of increased dose to left anterior descending coronary artery (LAD) in radiotherapy of breast cancer

    We have evaluated thoracic conformation of patients in order to derive a numeric value predictive of an increased dose to left anterior descending coronary artery (LAD), critical structure for the development ...

    R. Di Franco, V. Ravo, V. Nieddu, A. Crispo, S. Falivene, F. M. Giugliano, A. Argenone, V. Borzillo, F. Cammarota and P. Muto

    SpringerPlus 2016 5:841

    Published on: 23 June 2016

  6. Research

    Breast findings incidentally detected on body MRI

    To evaluate breast findings incidentally detected on body MRI.

    Bianca Bignotti, Giulia Succio, Francesca Nosenzo, Michela Perinetti, Licia Gristina, Stella Barbagallo, Lucia Secondini, Massimo Calabrese and Alberto Tagliafico

    SpringerPlus 2016 5:781

    Published on: 18 June 2016

  7. Research

    Worse and worse off: the impact of lymphedema on work and career after breast cancer

    Our study examines the impact of breast cancer-related lymphedema on women’s work and career. Our research addresses a significant knowledge gap regarding the additional impact of lymphedema on breast cancer s...

    John Boyages, Senia Kalfa, Ying Xu, Louise Koelmeyer, Helen Mackie, Hector Viveros, Lucy Taksa and Paul Gollan

    SpringerPlus 2016 5:657

    Published on: 17 May 2016

  8. Research

    Luminal B breast cancer subtype displays a dicotomic epigenetic pattern

    Luminal B breast tumors have aggressive clinical and biological features, and constitute the most heterogeneous molecular subtype, both clinically and molecularly. Unfortunately, the immunohistochemistry corre...

    Naiara G. Bediaga, Elena Beristain, Borja Calvo, María A. Viguri, Borja Gutierrez-Corres, Ricardo Rezola, Irune Ruiz-Diaz, Isabel Guerra and Marian M. de Pancorbo

    SpringerPlus 2016 5:623

    Published on: 14 May 2016

  9. Research

    Assessment of psychosocial factors and distress in women having adjuvant endocrine therapy for breast cancer: the relationship among emotional distress and patient and treatment-related factors

    The aims of this study were to comprehensively describe the psychosocial and medical characteristics of women who initiated tamoxifen or aromatase inhibitors for breast cancer and to compare levels of emotiona...

    Ozturk Ates, Cem Soylu, Taner Babacan, Furkan Sarici, Neyran Kertmen, Deborah Allen, Ali Riza Sever and Kadri Altundag

    SpringerPlus 2016 5:486

    Published on: 19 April 2016

  10. Research

    Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study

    The purpose of this exploratory candidate gene association study was to examine relationships between polymorphisms in oxidative stress and DNA repair genes and pre-adjuvant therapy cognitive function (CF) in ...

    Theresa A. Koleck, Catherine M. Bender, Susan M. Sereika, Adam M. Brufsky, Barry C. Lembersky, Priscilla F. McAuliffe, Shannon L. Puhalla, Priya Rastogi and Yvette P. Conley

    SpringerPlus 2016 5:422

    Published on: 9 April 2016

  11. Research

    Survival in patients with non-metastatic breast cancer treated with adjuvant trastuzumab in clinical practice

    The NSABP Trial B-31 and NCCTG Trial N9831 (B-31/N9831 trials, Romond et al. in N Engl J Med 353:1673–84, 2005. doi:10.​1056/​NEJMoa052122; Perez et al. ...

    Christopher M. Gallagher, Kenneth More, Anthony Masaquel, Tripthi Kamath, Annie Guerin, Raluca Ionescu-Ittu, Roy Nitulescu, Marjolaine Gauthier-Loiselle, Nicholas Sicignano, Elizabeth Butts, Eric Q. Wu and Brian Barnett

    SpringerPlus 2016 5:395

    Published on: 31 March 2016

  12. Research

    Isolated radial scar diagnosis by core-needle biopsy: Is surgical excision necessary?

    Radial scar and radial sclerosis (RS) are considered benign breast lesions with proliferative features. There is sparse literature on frequency of cancer upgrade in these patients without atypical features fou...

    Elizabeth Min Hui Kim, Andrea Hankins, Jamie Cassity, Dennis McDonald, Barbara White, Ron Rowberry, Sharon Dutton and Claire Snyder

    SpringerPlus 2016 5:398

    Published on: 31 March 2016

  13. Research

    cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer

    Epidemiologic studies have associated obesity with increased risk of the aggressive basal-like breast cancer (BBC) subtype. Hepatocyte growth factor (HGF) signaling through its receptor, cMET, is elevated in o...

    Alyssa J. Cozzo, Sneha Sundaram, Ottavia Zattra, Yuanyuan Qin, Alex J. Freemerman, Luma Essaid, David B. Darr, Stephanie A. Montgomery, Kirk K. McNaughton, J. Ashley Ezzell, Joseph A. Galanko, Melissa A. Troester and Liza Makowski

    SpringerPlus 2016 5:348

    Published on: 19 March 2016

  14. Research

    A phase II, multicenter, single-arm trial of eribulin as first-line chemotherapy for HER2-negative locally advanced or metastatic breast cancer

    The treatment goals for metastatic breast cancer (MBC) are prolonging survival and improving the quality of life. Eribulin, a non-taxane tubulin inhibitor, demonstrated improved survival in previous studies an...

    Tsutomu Takashima, Shinya Tokunaga, Seika Tei, Shigehiko Nishimura, Hidemi Kawajiri, Shinichiro Kashiwagi, Shigehito Yamagata, Satoru Noda, Takeo Nishimori, Yoko Mizuyama, Takeshi Sunami, Kenji Tezuka, Katsumi Ikeda, Yoshinari Ogawa, Naoyoshi Onoda, Tetsuro Ishikawa…

    SpringerPlus 2016 5:164

    Published on: 24 February 2016

  15. Research

    Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study

    Predicting the risk of sentinel lymph node (SLN) metastasis is important for clinical decision-making in the setting of early breast cancer (EBC). This study is aimed to identify tumor and patient characterist...

    Nicla La Verde, Elena Biagioli, Chiara Gerardi, Andrea Cordovana, Chiara Casiraghi, Irene Floriani, Elena Bernardin, Gabriella Farina, Serena Di Cosimo, Maria Chiara Dazzani and Giorgio Gherardi

    SpringerPlus 2016 5:114

    Published on: 3 February 2016

  16. Research

    Patterns in target-directed breast cancer research

    We undertake an analysis of ongoing BC targeted therapy trials registered to to describe patterns of ongoing clinical research, highlight gaps in current research programs and identify ways of optimizin...

    Sofia Torres, Christine Simmons, Jean-François Boileau, Deanna McLeod, Ilidio Martins and Maureen Trudeau

    SpringerPlus 2016 5:109

    Published on: 1 February 2016

  17. Research

    Risk of cancer-specific, cardiovascular, and all-cause mortality among Asian and Pacific Islander breast cancer survivors in the United States, 1991–2011

    Asian and Pacific Islander (API) women in the United States (U.S.) are a heterogeneous group reported to have better prognosis after breast cancer (BC) compared to their Non-Hispanic White (NHW) counterparts. ...

    Pooja A. Solanki, Naomi Y. Ko, Dima M. Qato and Gregory S. Calip

    SpringerPlus 2016 5:82

    Published on: 26 January 2016

  18. Research

    Eribulin in pretreated metastatic breast cancer patients: results of the TROTTER trial—a multicenter retrospective study of eribulin in real life

    This retrospective multicenter analysis was aimed to evaluate clinical activity and tolerability of eribulin in pretreated metastatic breast cancer patients in clinical practice. Patients treated with eribulin...

    Ornella Garrone, Filippo Montemurro, Chiara Saggia, Nicla La Verde, Anna Maria Vandone, Mario Airoldi, Enrico De Conciliis, Michela Donadio, Francesco Lucio, Maria Antonia Polimeni, Maria Vittoria Oletti, Alice Giacobino and Marco Carlo Merlano

    SpringerPlus 2016 5:59

    Published on: 21 January 2016

  19. Database

    Impact of race and tumor subtype on second malignancy risk in women with breast cancer

    Women with breast cancer are at increased risk of second malignancy (SM). However, the impact of race and the hormone receptor (HR) status of the primary breast tumor on risk of SM are not known. The purpose o...

    Nicholas Diab, Gary Clark, Lucy Langer, Yunfei Wang, Barbara Hamlington, Laura Brzeskiewicz, Joyce O’Shaughnessy, Sami Diab and Salma K. Jabbour

    SpringerPlus 2016 5:14

    Published on: 6 January 2016

  20. Research

    Dynamic contrast-enhanced breast MRI at 7T and 3T: an intra-individual comparison study

    The aim of this study is to compare the current state of lesion identification, the BI-RADS classification and the contrast-enhancement behavior at 7T and 3T breast MRI in the same patient group. Twenty-seven ...

    Gisela L. G. Menezes, Bertine L. Stehouwer, Dennis W. J. Klomp, Tijl A. van der Velden, Maurice A. A. J. van den Bosch, Floortje M. Knuttel, Vincent O. Boer, Wybe J. M. van der Kemp, Peter R. Luijten and Wouter B. Veldhuis

    SpringerPlus 2016 5:13

    Published on: 5 January 2016

    The Erratum to this article has been published in SpringerPlus 2016 5:1012

  21. Research

    MAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitro

    Recent investigations have highlighted that therapeutic artificial microRNAs could be promising candidates for cancer therapy through the modulation of tumor promoter or suppressor. MEK kinase 1 (MEKK1) is exp...

    Chun Liu, Shengjie Wang, Shunxing Zhu, Haifeng Wang, Jiayi Gu, Zeping Gui, Jin Jing, Xiaofan Hou and Yixiang Shao

    SpringerPlus 2016 5:11

    Published on: 4 January 2016

  22. Research

    Reproductive factors, tumor estrogen receptor status and contralateral breast cancer risk: results from the WECARE study

    Several reproductive factors are known to be associated with risk of breast cancer; however, relationships between these factors with risk of second primary asynchronous contralateral breast cancer (CBC) have ...

    Julia S. Sisti, Jonine L. Bernstein, Charles F. Lynch, Anne S. Reiner, Lene Mellemkjaer, Jennifer D. Brooks, Julia A. Knight, Leslie Bernstein, Kathleen E. Malone, Meghan Woods, Xiaolin Liang and Esther M. John

    SpringerPlus 2015 4:825

    Published on: 30 December 2015

  23. Research

    Cost effectiveness of personalized treatment in women with early breast cancer: the application of OncotypeDX and Adjuvant! Online to guide adjuvant chemotherapy in Austria

    A Breast Cancer Outcomes model was developed at the ONCOTYROL research center to evaluate personalized test-treatment strategies in Austria. The goal was to evaluate the cost-effectiveness of a new 21-gene ass...

    B. Jahn, U. Rochau, C. Kurzthaler, M. Hubalek, R. Miksad, G. Sroczynski, M. Paulden, M. Kluibenschädl, M. Krahn and U. Siebert

    SpringerPlus 2015 4:752

    Published on: 1 December 2015

  24. Research

    High incidence of triple negative breast cancers following pregnancy and an associated gene expression signature

    Breast cancer risk increases transiently in the period following pregnancy; pregnancy-associated breast cancers (PABC) are more aggressive than cases diagnosed in nulliparous women. We have previously reported...

    Szilard Asztalos, Thao N. Pham, Peter H. Gann, Meghan K. Hayes, Ryan Deaton, Elizabeth L. Wiley, Rajyasree Emmadi, Andre Kajdacsy-Balla, Nilanjana Banerji, William McDonald, Seema A. Khan and Debra A. Tonetti

    SpringerPlus 2015 4:710

    Published on: 19 November 2015

  25. Research

    Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

    Acquired or de novo resistance to the selective estrogen receptor modulators tamoxifen and fulvestrant (ICI) is a major barrier to successful treatment of breast cancer. Gene expression patterns in tamoxifen r...

    William Walter, Jennifer Thomalla, Josh Bruhn, Dedra H. Fagan, Cheryl Zehowski, Douglas Yee and Andrew Skildum

    SpringerPlus 2015 4:689

    Published on: 10 November 2015

  26. Research

    Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer

    Peritoneal metastasis from breast cancer is a serious and deadly condition only limited considered in the literature. Our aim was to study prevalence, risk factors, and prognosis of breast cancer peritoneal m...

    Serena Bertozzi, Ambrogio P. Londero, Carla Cedolini, Alessandro Uzzau, Luca Seriau, Sergio Bernardi, Stefano Bacchetti, Enrico Maria Pasqual and Andrea Risaliti

    SpringerPlus 2015 4:688

    Published on: 10 November 2015

  27. Research

    Mastectomy rates remain high in Singapore and are not associated with poorer survival after adjusting for age

    Recent reports have suggested that women undergoing mastectomy, instead of wide local excision (WLE) for Stage I and II breast cancers have poorer overall survival. This is particularly important in our settin...

    Patrick M. Y. Chan, Bok Ai Choo, Tianjiao Zhang, Melanie D. W. Seah, Juliana J. C. Chen, Sarah Q. H. Lu and Ern Yu Tan

    SpringerPlus 2015 4:685

    Published on: 10 November 2015

  28. Research

    Step by step approach to rare breast lesions containing spindle cells

    Differential diagnosis of spindle cell lesions of breast is challenging for certain reasons. The most important reason is the presence of cytological atypia and mitosis in all three conditions: reactive, benig...

    Betül Ünal, Gülgün Erdoğan and Fatma Şeyda Karaveli

    SpringerPlus 2015 4:678

    Published on: 5 November 2015

  29. Research

    Comparison of five different popular scoring systems to predict nonsentinel lymph node status in patients with metastatic sentinel lymph nodes: a tertiary care center experience

    Sentinel lymph node biopsy (SLNB) is the current standard of care for breast cancers with no clinically palpable axillary lymph nodes. Almost 50 % of sentinel lymph node positive patients have negative non-sen...

    Ramazan Yıldız, Murat Urkan, Oğuz Hancerliogulları, Zafer Kılbaş, Erkan Ozturk, Mustafa Oner Mentes and Semih Gorgulu

    SpringerPlus 2015 4:651

    Published on: 29 October 2015

  30. Research

    Promoter methylation of TRIM9 as a marker for detection of circulating tumor DNA in breast cancer patients

    The aim of the present study was to investigate the promoter methylation status of TRIM9 in breast cancer and to determine the presence of TRIM9-methylated circulating tumor DNA (ctDNA) in plasma. Bisulfite sequ...

    Chieko Mishima, Naofumi Kagara, Saki Matsui, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Atsushi Shimomura, Kenzo Shimazu, Seung Jin Kim and Shinzaburo Noguchi

    SpringerPlus 2015 4:635

    Published on: 22 October 2015

  31. Review

    Mammography screening in less developed countries

    Less developed countries (LDCs) are struggling with an increasing burden of breast cancer. It is important to identify what interventions might be most effective and feasible in reducing overall breast cancer ...

    JunJie Li and ZhiMin Shao

    SpringerPlus 2015 4:615

    Published on: 15 October 2015

  32. Research

    Impact of prior anthracycline or taxane use on eribulin effectiveness as first-line treatment for metastatic breast cancer: results from two phase 2, multicenter, single-arm studies

    Eribulin mesylate has efficacy in patients who have received ≥2 prior chemotherapies for metastatic breast cancer (MBC) including an anthracycline and taxane. Phase 2 trials showed clinical activity and accept...

    Joyce O’Shaughnessy, Kristi McIntyre, Lee Schwartzberg, Sharon Wilks, Shannon Puhalla, Erhan Berrak, James Song and Linda Vahdat

    SpringerPlus 2015 4:532

    Published on: 21 September 2015

  33. Research

    Different types of tumor vessels in breast cancer: morphology and clinical value

    Angiogenesis is a key factor of tumor progression. Considering, that the tumor vessels are heterogeneous and differ in morphology and clinical significance, the purpose of this research was to study of the mor...

    Marina A. Senchukova, Natalia V. Nikitenko, Olesia N. Tomchuk, Nikon V. Zaitsev and Alexander A. Stadnikov

    SpringerPlus 2015 4:512

    Published on: 17 September 2015

  34. Research

    Accurate evaluation of axillary sentinel lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid in breast cancer: a preliminary clinical trial

    Breast cancer is the most common type of cancer in women. The 5-year survival rate in patients with breast cancer ranges from 74 to 82 %. Sentinel lymph node biopsy has become an alternative to axillary lymph ...

    Fumihiko Matsuzawa, Kiyoka Omoto, Takahiro Einama, Hironori Abe, Takashi Suzuki, Jun Hamaguchi, Terumi Kaga, Mami Sato, Masako Oomura, Yumiko Takata, Ayako Fujibe, Chie Takeda, Etsuya Tamura, Akinobu Taketomi and Kenichi Kyuno

    SpringerPlus 2015 4:509

    Published on: 17 September 2015

  35. Research

    Pro-oncogenic cytokines and growth factors are differentially expressed in the post-surgical wound fluid from malignant compared to benign breast lesions

    The accumulation of wound fluid known as seroma in the chest cavity following breast surgery is a common occurrence that can persist for many weeks. While the pro-inflammatory composition of seroma is well est...

    Amanda Valeta-Magara, Raheleh Hatami, Deborah Axelrod, Daniel F. Roses, Amber Guth, Silvia C. Formenti and Robert J. Schneider

    SpringerPlus 2015 4:483

    Published on: 5 September 2015

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