Recent clinical findings from cohort studies and large prospective interventional trials improved the knowledge in the area of the metabolic response to critical illness. For instance, early high energy and protein intakes have been associated with adverse outcomes by various investigators, while the benefits of intensive insulin therapy are reconsidered. Simultaneously, the importance of the monitoring and management of micronutrients has been highlighted. The nutritional modulation of the persisting inflammatory response is supported by preclinical data.
Hence, the clinical management of nutrition in the critically ill patient is changing following the improved understanding of the physiology of the successive post-injury phases. The collection entitled « Metabolic and nutritional aspects of critical illness» aims to summarize the current knowledge in the areas of timing of the metabolic response to stress, glycemic control, optimal energy and protein intakes, the management of micronutrients and nutritional modulation to resolve inflammation.
We hope that the invited international contributions to this collection will help translate the recent findings into improvements in the quality of care by individualized metabolic and nutritional management.
Unsolicited submissions are welcome.