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Computational Systems Biology 2011

  1. Transcriptional regulation networks are often modeled as Boolean networks. We discuss certain properties of Boolean functions (BFs), which are considered as important in such networks, namely, membership to th...

    Authors: Johannes Georg Klotz, Ronny Feuer, Oliver Sawodny, Martin Bossert, Michael Ederer and Steffen Schober

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2013 2013:1

    Content type: Research

    Published on:

  2. Performing quantitative, highly sensitive measurements at a single molecule level is often necessary to address specific issues related to complex molecular and biochemical systems. For that purpose, we presen...

    Authors: Martin Gerald Puchinger, Clemens Alexander Zarzer, Philipp Kügler, Erwin Gaubitzer and Gottfried Köhler

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:17

    Content type: Research

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  3. Bacterial strains that were genetically blocked in important metabolic pathways and grown under selective conditions underwent a process of adaptive evolution: certain pathways may have been deregulated and th...

    Authors: Ronny Feuer, Katrin Gottlieb, Gero Viertel, Johannes Klotz, Steffen Schober, Martin Bossert, Oliver Sawodny, Georg Sprenger and Michael Ederer

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:14

    Content type: Research

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  4. We describe some new conceptual tools for the rigorous, mathematical description of the “set-complexity” of graphs. This set-complexity has been shown previously to be a useful measure for analyzing some biolo...

    Authors: Tomasz M Ignac, Nikita A Sakhanenko and David J Galas

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:13

    Content type: Research

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  5. In the yeast Saccharomyces cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of cell growth and proliferation in response to nutritional sensing and stress conditions. The pathway is tightly regu...

    Authors: Daniela Besozzi, Paolo Cazzaniga, Dario Pescini, Giancarlo Mauri, Sonia Colombo and Enzo Martegani

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:10

    Content type: Research

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  6. Recent experimental imaging techniques are able to tag and count molecular populations in a living cell. From these data mathematical models are inferred and calibrated. If small populations are present, discr...

    Authors: Aleksandr Andreychenko, Linar Mikeev, David Spieler and Verena Wolf

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:9

    Content type: Research

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  7. In our previous study, we introduced a combination methodology of Fluorescence Correlation Spectroscopy (FCS) and Transmission Electron Microscopy (TEM), which is powerful to investigate the effect of intracel...

    Authors: Noriko Hiroi, Michael Klann, Keisuke Iba, Pablo de Heras Ciechomski, Shuji Yamashita, Akito Tabira, Takahiro Okuhara, Takeshi Kubojima, Yasunori Okada, Kotaro Oka, Robin Mange, Michael Unger, Akira Funahashi and Heinz Koeppl

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:7

    Content type: Research

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  9. In recent years, cell population models have become increasingly common. In contrast to classic single cell models, population models allow for the study of cell-to-cell variability, a crucial phenomenon in mo...

    Authors: Jan Hasenauer, Julian Heinrich, Malgorzata Doszczak, Peter Scheurich, Daniel Weiskopf and Frank Allgöwer

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:4

    Content type: Research

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  10. The identification of molecular target and mechanism of action of compounds is a key hurdle in drug discovery. Multiplexed techniques for bead-based expression profiling allow the measurement of transcriptiona...

    Authors: Florian Nigsch, Janna Hutz, Ben Cornett, Douglas W Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro and Jeremy L Jenkins

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:2

    Content type: Research

    Published on: