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Biomarkers in critically ill patients

Guest Editors:
Antonio Artigas: Parc Tauli University Hospital, Spain
Lorraine B. Ware: Vanderbilt University School Of Medicine, USA

Submission Status: Open

Annals of Intensive Care is presenting a new Collection on the "Biomarkers in critically ill patients". Key topics we would like to cover are: early diagnosis, risk assessment, treatment response, biological feasibility, ease of measurement, rapid results, and cost-benefit analysis.

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About the collection

In recent years, the use of biomarkers in the ICU has surged. Biomarker research across medical fields has seen significant growth since the 1980s, aided by technological advancements. However, progress in critical care has been slower due to the complex and heterogeneous nature of critical illnesses.

Accurate biomarkers for diagnosis, prediction, and prognosis would greatly enhance our understanding of these conditions. Exciting advancements in point-of-care testing technologies offer potential for transforming biomarker application at the bedside, enabling diagnosis, risk stratification, molecular phenotyping, and monitoring treatment response. Biomarker panels, rather than single analytes, are being increasingly used to decrease costs. It is important to combine biomarkers with physician expertise and clinical judgment. Newer omic markers like transcriptomics, metabolomics, and genomics hold promise for personalized medicine. Validated biomarkers will enable accurate prediction, diagnosis, targeted treatments, and define treatment duration and short-term outcomes.

Analyzing large ICU datasets using AI can identify risk factors, prognosis, and outcomes for critically ill patients.

Key topics we would like to cover in this collection include: early diagnosis, risk assessment, treatment response, biological feasibility, ease of measurement, rapid results, and cost-benefit analysis.

  1. Severe acute respiratory infections, such as community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, constitute frequent and lethal pulmonary infections in the intensive...

    Authors: Pedro Póvoa, Luís Coelho, José Pedro Cidade, Adrian Ceccato, Andrew Conway Morris, Jorge Salluh, Vandack Nobre, Saad Nseir, Ignacio Martin-Loeches, Thiago Lisboa, Paula Ramirez, Anahita Rouzé, Daniel A. Sweeney and Andre C. Kalil
    Citation: Annals of Intensive Care 2024 14:113
  2. The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients.

    Authors: Ryohei Horie, Naoki Hayase, Toshifumi Asada, Miyuki Yamamoto, Takehiro Matsubara and Kent Doi
    Citation: Annals of Intensive Care 2024 14:84
  3. The renin-angiotensin system (RAS) constitutes one of the principal mechanisms to maintain hemodynamic and fluid homeostasis. However, most research until now on RAS primarily focuses on its relationship with ...

    Authors: Yuki Kotani, Mark Chappell, Giovanni Landoni, Alexander Zarbock, Rinaldo Bellomo and Ashish K. Khanna
    Citation: Annals of Intensive Care 2024 14:79

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via the submission system. During the submission process you will be asked whether you are submitting to a Collection, please select "Long-term outcomes after critical illness" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.