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G protein-coupled receptors: computer-aided ligand discovery and computational structural analysis in the 2010s

Dr Stefano Costanzi

  1. Content type: Original research

    G Protein-Coupled Receptors (GPCRs) are a large family of therapeutically important proteins and as diverse X-ray structures become available it is increasingly possible to leverage structural information for ...

    Authors: Jonathan S Mason, Andrea Bortolato, Dahlia R Weiss, Francesca Deflorian, Benjamin Tehan and Fiona H Marshall

    Citation: In Silico Pharmacology 2013 1:23

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  2. Content type: Original research

    A2B receptor agonists are studied as possible therapeutic tools for a variety of pathological conditions. Unfortunately, medicinal chemistry efforts have led to the development of a limited number of potent agoni...

    Authors: Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Ajiroghene Thomas and Rosaria Volpini

    Citation: In Silico Pharmacology 2013 1:24

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  3. Content type: Short report

    Adenosine receptors (ARs) belong to the G protein-coupled receptors (GCPRs) family. The recent release of X-ray structures of the human A2A AR (h A2A AR ) in complex with agonists and antagonists has increased th...

    Authors: Matteo Floris, Davide Sabbadin, Antonella Ciancetta, Ricardo Medda, Alberto Cuzzolin and Stefano Moro

    Citation: In Silico Pharmacology 2013 1:25

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  4. Content type: Original research

    G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins of vast pharmaceutical interest. Here, we describe a graph theory-based analysis of the structure of the β2 adrenergic receptor (β2 AR), ...

    Authors: Samuel Sheftel, Kathryn E Muratore, Michael Black and Stefano Costanzi

    Citation: In Silico Pharmacology 2013 1:16

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