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Computational Pharmacokinetics

Prof Frederic Bois

  1. Commentary

    Drug-target and disease networks: polypharmacology in the post-genomic era

    With the growing understanding of complex diseases, the focus of drug discovery has shifted away from the well-accepted “one target, one drug” model, to a new “multi-target, multi-drug” model, aimed at systemi...

    Ali Masoudi-Nejad, Zaynab Mousavian and Joseph H Bozorgmehr

    In Silico Pharmacology 2013 1:17

    Published on: 5 December 2013

  2. Original research

    Quantitative In Silico analysis of transient metabolism of acetaminophen and associated causes of hepatotoxicity in humans

    Although safe at therapeutic levels, excess intake of acetaminophen can lead to hepatic injury or acute liver failure (ALF). A number of different factors influence metabolism and hepatotoxicity of acetaminoph...

    Ali Navid, David M Ng, Benjamin J Stewart, Sergio E Wong and Felice C Lightstone

    In Silico Pharmacology 2013 1:14

    Published on: 4 November 2013

  3. Original research

    In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin

    Drug metabolism and pharmacokinetics (DMPK) assessment has come to occupy a place of interest during the early stages of drug discovery today. The use of computer modelling to predict the DMPK and toxicity pro...

    Fidele Ntie-Kang, Lydia L Lifongo, James A Mbah, Luc C Owono Owono, Eugene Megnassan, Luc Meva’a Mbaze, Philip N Judson, Wolfgang Sippl and Simon M N Efange

    In Silico Pharmacology 2013 1:12

    Published on: 8 August 2013

  4. Original research

    The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance

    Developing a user-friendly platform that can handle a vast number of complex physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models both for conventional small molecules and larger biologic...

    Masoud Jamei, Steve Marciniak, Duncan Edwards, Kris Wragg, Kairui Feng, Adrian Barnett and Amin Rostami-Hodjegan

    In Silico Pharmacology 2013 1:9

    Published on: 3 June 2013

  5. Editorial

    Computational pharmacokinetics at a crossroads

    This first special issue of In Silico Pharmacology focuses on computational pharmacokinetics since they are an important part of integrated applications in computational pharmacology. The important topics of mode...

    Frédéric Y Bois

    In Silico Pharmacology 2013 1:5

    Published on: 6 March 2013

  6. Original research

    Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz

    To treat malaria, HIV-infected patients normally receive artemether (80 mg twice daily) concurrently with antiretroviral therapy and drug-drug interactions can potentially occur. Artemether is a substrate of C...

    Marco Siccardi, Adeniyi Olagunju, Kay Seden, Farid Ebrahimjee, Steve Rannard, David Back and Andrew Owen

    In Silico Pharmacology 2013 1:4

    Published on: 1 March 2013