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Recent advances in pediatric gut diseases

  1. Mini review

    The cross-talk between enterocytes and intraepithelial lymphocytes

    The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...

    Serena Vitale, Stefania Picascia and Carmen Gianfrani

    Molecular and Cellular Pediatrics 2016 3:20

    Published on: 1 June 2016

  2. Mini review

    The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens

    The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...

    Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede and Hassan Y. Naim

    Molecular and Cellular Pediatrics 2016 3:14

    Published on: 22 March 2016

  3. Mini review

    Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis

    Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...

    Speranza Esposito, Antonella Tosco, Valeria R. Villella, Valeria Raia, Guido Kroemer and Luigi Maiuri

    Molecular and Cellular Pediatrics 2016 3:13

    Published on: 14 March 2016

  4. Mini review

    Fructose malabsorption

    Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Karolin Ebert and Heiko Witt

    Molecular and Cellular Pediatrics 2016 3:10

    Published on: 16 February 2016

  5. Mini review

    Endocytosis and transcytosis of gliadin peptides

    Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...

    M. Vittoria Barone and K. Peter Zimmer

    Molecular and Cellular Pediatrics 2016 3:8

    Published on: 16 February 2016

  6. Mini review

    Diverse roles of endoplasmic reticulum stress sensors in bacterial infection

    Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...

    Helena Pillich, Maria Loose, Klaus-Peter Zimmer and Trinad Chakraborty

    Molecular and Cellular Pediatrics 2016 3:9

    Published on: 16 February 2016

  7. Mini review

    Genetics of irritable bowel syndrome

    Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...

    Maria Henström and Mauro D’Amato

    Molecular and Cellular Pediatrics 2016 3:7

    Published on: 12 February 2016

  8. Mini review

    The clinical consequences of sucrase-isomaltase deficiency

    Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...

    Stanley A. Cohen

    Molecular and Cellular Pediatrics 2016 3:5

    Published on: 8 February 2016

  9. Mini review

    Milk glucosidase activity enables suckled pup starch digestion

    Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...

    B. L. Nichols, M. Diaz-Sotomayor, S. E. Avery, S. K. Chacko, D. L. Hadsell, S. S. Baker, B. R. Hamaker, L. K. Yan, H. M. Lin and R. Quezada-Calvillo

    Molecular and Cellular Pediatrics 2016 3:4

    Published on: 1 February 2016

  10. Mini review

    Towards understanding microvillus inclusion disease

    Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...

    Georg F. Vogel, Michael W. Hess, Kristian Pfaller, Lukas A. Huber, Andreas R. Janecke and Thomas Müller

    Molecular and Cellular Pediatrics 2016 3:3

    Published on: 29 January 2016

  11. Mini review

    The multiple roles of sucrase-isomaltase in the intestinal physiology

    Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of microvillar disaccharidases. Disaccharidases are crucia...

    Birthe Gericke, Mahdi Amiri and Hassan Y. Naim

    Molecular and Cellular Pediatrics 2016 3:2

    Published on: 26 January 2016

  12. Mini review

    The role of hypoxia in intestinal inflammation

    Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...

    Yatrik M. Shah

    Molecular and Cellular Pediatrics 2016 3:1

    Published on: 26 January 2016