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Recent advances in pediatric gut diseases

  1. Content type: Mini review

    The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells gua...

    Authors: Serena Vitale, Stefania Picascia and Carmen Gianfrani

    Citation: Molecular and Cellular Pediatrics 2016 3:20

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  2. Content type: Mini review

    The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted...

    Authors: Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede and Hassan Y. Naim

    Citation: Molecular and Cellular Pediatrics 2016 3:14

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  3. Content type: Mini review

    Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concent...

    Authors: Speranza Esposito, Antonella Tosco, Valeria R. Villella, Valeria Raia, Guido Kroemer and Luigi Maiuri

    Citation: Molecular and Cellular Pediatrics 2016 3:13

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  4. Content type: Mini review

    Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Authors: Karolin Ebert and Heiko Witt

    Citation: Molecular and Cellular Pediatrics 2016 3:10

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  5. Content type: Mini review

    Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...

    Authors: M. Vittoria Barone and K. Peter Zimmer

    Citation: Molecular and Cellular Pediatrics 2016 3:8

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  6. Content type: Mini review

    Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there...

    Authors: Helena Pillich, Maria Loose, Klaus-Peter Zimmer and Trinad Chakraborty

    Citation: Molecular and Cellular Pediatrics 2016 3:9

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  7. Content type: Mini review

    Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced...

    Authors: Maria Henström and Mauro D’Amato

    Citation: Molecular and Cellular Pediatrics 2016 3:7

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  8. Content type: Mini review

    Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express ...

    Authors: Stanley A. Cohen

    Citation: Molecular and Cellular Pediatrics 2016 3:5

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  9. Content type: Mini review

    Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase. All are deficient in suckling...

    Authors: B. L. Nichols, M. Diaz-Sotomayor, S. E. Avery, S. K. Chacko, D. L. Hadsell, S. S. Baker, B. R. Hamaker, L. K. Yan, H. M. Lin and R. Quezada-Calvillo

    Citation: Molecular and Cellular Pediatrics 2016 3:4

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  10. Content type: Mini review

    Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical mic...

    Authors: Georg F. Vogel, Michael W. Hess, Kristian Pfaller, Lukas A. Huber, Andreas R. Janecke and Thomas Müller

    Citation: Molecular and Cellular Pediatrics 2016 3:3

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  11. Content type: Mini review

    Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory re...

    Authors: Yatrik M. Shah

    Citation: Molecular and Cellular Pediatrics 2016 3:1

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