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Headache and Pain

Edited by: Professor Paolo Martelletti and Professor Maria Adele Giamberardino

The Headache and Pain Collection is a new venue for research in the field of headache disorders and pain and publishes original research on the impact, epidemiology, nature, mechanisms and treatment of all forms of headache and pain. The Collection provides a platform for the dissemination of research in the basic and clinical sciences from a multidisciplinary point of view.

Articles published in SpringerPlus: Headache and Pain Collection are linked to The Journal of Headache and Pain.

The Headache and Pain Collection is a sister title of The Journal of Headache and Pain, providing a new Open Access forum for publication of scientifically valuable manuscripts.

Click here to view all members of the collection's editorial board.

Subject matters for the sister Collection include (in humans and other animals):

  • epidemiology
  • public health
  • biochemistry
  • biomedicine
  • food science
  • immunology
  • physiology
  • pharmacology
  • toxicology
  • peptides
  • genetics

All manuscripts are subject to rigorous peer reviews for their suitability of publication in SpringerPlus.

As Editors in Chief of this Collection, we offer you a new platform, SpringerPlus: Headache and Pain Collection, as home of your research.

Paolo Martelletti

Meet the Editors

Professor Paolo Martelletti is Professor of Internal Medicine and Director and Master in Headache Medicine at the Sapienza University of Rome. Other posts include: Director of the Regional Referral Headache Centre, Sant’Andrea Hospital, Rome; Chairman of Lifting The Burden, The Global Campaign against Headache (2009-2014); President-Elect, European Headache Federation (2014-2016); Editor-in-Chief (Founding), The Journal of Headache and Pain, Springer (2004-2015).

Maria Adele Giamberardino


Maria Adele Giamberardino, MD, lives and works in Chieti, where she is Associate Professor of Internal Medicine (since 1999), Research Director of the “Pathophysiology of Pain Laboratory” (since 1994), Head of the “Center for Fibromyalgia and Musculoskeletal Pain” (since 2000) and of the “Headache Center” (since 2005) at the Department of Medicine and Science of Aging of the “G. D’Annuznio” University.

Submission Instructions

If your manuscript meets the aims and scope of this individual Collection, please first follow all of the SpringerPlus Submission Guidelines.

During submission, at the "Additional Information" section, please select that you are submitting to an Article Collection, and choose “Headache and Pain” from the list.

Collection Articles:

  1. Content type: Research

    The Comprehensive Headache-related Quality of life Questionnaire (CHQQ), is a recently developed and validated instrument, intended for measuring quality of life of patients with all headache types. Currently ...

    Authors: Slobodan M. Jankovic, Marija Andjelkovic, Radica Zivkovic Zaric, Marko Vasic, Éva Csépány, Tamás Gyüre and Csaba Ertsey

    Citation: SpringerPlus 2016 5:1416

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  2. Content type: Research

    Local anesthetic infiltration has been used to manage postoperative pain in various surgeries. The present study was aimed to investigate the effect of skin infiltration with 0.5 % ropivacaine on postoperative...

    Authors: Hongyu Zhou, Mengchan Ou, Yaoxin Yang, Qian Ruan, Yan Pan and Yu Li

    Citation: SpringerPlus 2016 5:1180

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  3. Content type: Research

    Behcet’s disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet’s disease. It might be a pa...

    Authors: Maryam Moghaddassi, Mansoureh Togha, Farhad Shahram, Hamed Hanif, Sahar Dadkhah, Soodeh Razeghi Jahromi and Mohammad Mozafari

    Citation: SpringerPlus 2016 5:1077

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  4. Content type: Research

    Chronic migraine is a disabling condition that impacts multiple aspects of migraineurs’ lives. Although pharmacological treatments can help to treat the pain associated with migraine headache, chronic migraine...

    Authors: Jieun Lee, Amrita Bhowmick and Amy Wachholtz

    Citation: SpringerPlus 2016 5:1006

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  5. Content type: Research

    Patients suffering from migraine or tension-type headache (TTH) often treat their complaints with over-the-counter (OTC) medications. Fixed dose combinations of acetylsalicylic acid, paracetamol and caffeine (...

    Authors: Charly Gaul, Heidemarie Gräter and Thomas Weiser

    Citation: SpringerPlus 2016 5:721

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  6. Content type: Review

    Migraine is a common and highly disabling neurological disorder associated with a high socioeconomic burden. Effective migraine management depends on adequate patient education: to avoid unrealistic expectati...

    Authors: Fabio Antonaci, Natascia Ghiotto, Shizheng Wu, Ennio Pucci and Alfredo Costa

    Citation: SpringerPlus 2016 5:637

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  7. Content type: Research

    BoNT-A is often used in the clinical treatment for movement disorders. In recent years, various clinical studies suggest that BoNT-A can effectively alleviate pain caused by trigeminal neuralgia (TN); however,...

    Authors: Chuanjie Wu, Nanchang Xie, Yajun Lian, Hongliang Xu, Chen Chen, Yake Zheng, Yuan Chen and Haifeng Zhang

    Citation: SpringerPlus 2016 5:431

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  8. Content type: Case study

    The trigeminal autonomic cephalagias (TACs) are short-lasting unilateral headaches associated with autonomic features. Even if coexistence of different ipsilateral TACs in the same patient has been previously ...

    Authors: Pauri Flavia and Lepre Chiara

    Citation: SpringerPlus 2016 5:396

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    The Erratum to this article has been published in SpringerPlus 2017 5:2120

  9. Content type: Research

    Linear headache (LH) has recently been described as a paroxysmal or continuous fixed head pain restricted in a linear trajectory of 5–10 mm in width, linking one endpoint in occipital or occipitocervical regio...

    Authors: Ya-Nan Lu, Qing-Qing Pan, Jie-Feng Pan, Lei Wang, Yun-Yun Lu, Liang-Hui Hu and Yu Wang

    Citation: SpringerPlus 2016 5:347

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  10. Content type: Research

    Injection of fibrin glue mixed with blood into the epidural space to reliably and effectively treat medically refractory orthostatic headache caused by spinal cerebrospinal fluid (CSF) leaks and subsequent int...

    Authors: Justin J. Elwood, Misha Dewan, Jolene M. Smith, Bahram Mokri, William D. Mauck and Jason S. Eldrige

    Citation: SpringerPlus 2016 5:317

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    The Erratum to this article has been published in SpringerPlus 2016 5:960

  11. Content type: Case study

    Linear headache (LH) has recently been described as a paroxysmal or continuous head pain restricted in a linear trajectory of 5–10 mm in width, linking one endpoint in occipital or occipitocervical region with...

    Authors: Lei Wang, Jie-Feng Pan, Yun-Yun Lu, Liang-Hui Hu, Ya-Nan Lu, Qing-Qing Pan and Yu Wang

    Citation: SpringerPlus 2016 5:315

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  12. Content type: Research

    This study was designed to compare the presence of seven clinical signs in a group of patients with migraine with that of patients with non-migraine headache. Migraine is sometimes misdiagnosed. Therefore addi...

    Authors: M. A. A. K. Munasinghe, Vajira Weerasinghe and M. A. S. C. Samarakoon

    Citation: SpringerPlus 2016 5:194

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  13. Content type: Review

    Despite the availability of generic antiepileptic drugs (AEDs), still patients and neurologists hesitate to make a switch due to assorted reasons. The objectives of this review were to evaluate the risks assoc...

    Authors: Muhammad Atif, Muhammad Azeem and Muhammad Rehan Sarwar

    Citation: SpringerPlus 2016 5:182

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  14. Content type: Research

    The efficacy and safety of OnabotulinumtoxinA 155-195 U (BOTOX®) in adults with chronic migraine (CM) were demonstrated in both the Phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) studies. Ho...

    Authors: Andrea Negro, Martina Curto, Luana Lionetto, Dorotea Crialesi and Paolo Martelletti

    Citation: SpringerPlus 2015 4:826

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  15. Content type: Research

    To examine prevalence of mental health problems among adolescents with chronic headache and compare internal and external coping strategies in young people with chronic headaches with and without mental health...

    Authors: Silje Hartberg, Jocelyne Clench-Aas, Ruth Kjærsti Raanaas and Christofer Lundqvist

    Citation: SpringerPlus 2015 4:801

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  16. Content type: Case Study

    Facial pain can be a management challenge. Peripheral nerve/field stimulation may be an effective option for refractory cases, but direct muscle stimulation with facial twitching may result. Botulinum toxin in...

    Authors: Terrence L. Trentman, Jillian A. Maloney, Christopher S. Wie, Alanna M. Rebecca and David M. Rosenfeld

    Citation: SpringerPlus 2015 4:671

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  17. Content type: Research

    Cervicogenic headaches are a nosologic entity recently recognized. In our common practice, we have noticed a relative frequency of the atlas spina-bifida occulta during the brain CT scan realized for headaches...

    Authors: Amégninou Mawuko Yao Adigo, Lama Kegdigoma Agoda-Kousséma, Ignéza Komi Agbotsou, Kokou Adambounou, Kpalma Duga Bakpatina-Batako, Oni Djagnikpo and Komlanvi Victor Adjénou

    Citation: SpringerPlus 2015 4:605

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  18. Content type: Research

    Chronic migraine affects 2 % of the population and has substantial impact on quality of life and considerable burden on healthcare resources. 50–80 % patients with chronic migraine have excessive consumption o...

    Authors: Fayyaz Ahmed, Hassan W. Zafar, Alina Buture and Modar Khalil

    Citation: SpringerPlus 2015 4:589

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  19. Content type: Case study

    Fungal sellar abscess is rare. A 42-year-old man was admitted with 2-month headache characterized by right peri-orbital pain. An intrasellar mass was found to be simulated a pituitary neoplasm after magnetic r...

    Authors: Wenyao Hong, Yuqing Liu, Mingwu Chen, Kun Lin, Zhengjian Liao and Shengyue Huang

    Citation: SpringerPlus 2015 4:550

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  20. Content type: Research

    OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) after publication of PREEMPT trials. Thus, we set out to evaluate the efficacy of OnabotA in a series of patients with CM treate...

    Authors: María Isabel Pedraza, Carolina de la Cruz, Marina Ruiz, Luis López-Mesonero, Elena Martínez, Mercedes de Lera and Ángel Luis Guerrero

    Citation: SpringerPlus 2015 4:176

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  21. Content type: Short report

    Demyelinating plaques may induce headache through disruption of the pathways, which are implicated in the pathogeneses of migraine. We report a case of 25-year-old female patient, who presented with status mig...

    Authors: Raed Alroughani, Samar F Ahmed, Riyadh Khan and Jasem Al-Hashel

    Citation: SpringerPlus 2015 4:28

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  22. Content type: Case study

    Intracranial hypotension (IH) occurs typically spontaneous and is a potentially life-threatening condition characterized by symptoms varying from postural headache to coma, with classical magnetic resonance im...

    Authors: Asita S Sarrafzadeh, Stephanie A Hopf, Oliver P Gautschi, Ana-Paula Narata and Karl Schaller

    Citation: SpringerPlus 2014 3:153

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  23. Content type: Review

    Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. Symptomatic cases have been described, for example tumours, dissections and infections, but a causa...

    Authors: Bengt Edvardsson

    Citation: SpringerPlus 2014 3:64

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  24. Content type: Short report

    Cyproheptadine hydrochloride (CH) is rarely used to treat adult patients with migraine in Japan because it causes sleepiness. In this study, we investigated the preventive effect of CH in 12 patients who had f...

    Authors: Hirohisa Okuma, Kazuyuki Iijima, Takashi Yasuda, Kentaro Tokuoka and Yasuhisa Kitagawa

    Citation: SpringerPlus 2013 2:573

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  25. Content type: Case study

    Cerebral hyperperfusion syndrome is a well-recognized and potentially fatal complication of carotid revascularization. However, the occurrence of non-aneurysmal subarachnoid hemorrhage as a manifestation of ce...

    Authors: Gopiga Thanabalasundaram, Silvia Hernández-Durán, Thabele Leslie-Mazwi and Christopher S Ogilvy

    Citation: SpringerPlus 2013 2:571

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  26. Content type: Research

    To evaluate if white matter lesions (WML) on MRI can be a potential marker for onabotulinum toxin A (Botox®) treatment success in migraine, given the limited response rate and high costs per treatment.

    Authors: Anja Bumb, Burkhard Seifert, Stephan Wetzel and Reto Agosti

    Citation: SpringerPlus 2013 2:377

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  27. Content type: Letter to the Editor

    The authors developed a computerized program designed to diagnose primary headache based on international classification of headache disorders, 2nd edition (ICHD-II) criteria for use by physicians.

    Authors: Vahid Eslami, Sadreddin Rouhani-Esfahani, Nima Hafezi-Nejad, Farshid Refaeian, Siamak Abdi and Mansoureh Togha

    Citation: SpringerPlus 2013 2:199

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  28. Content type: Research

    The international Headache Society (I H S) diagnostic criteria (International classification of headache disorders edition 2- ICHD 2) for headache in children and adults improved the accuracy of migraine diagn...

    Authors: Muttamthottil Varghese Francis

    Citation: SpringerPlus 2013 2:77

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  29. Content type: Research

    In a recent meta-analysis migraine was associated with a two-fold increase in stroke risk. While the mechanism driving this association is unknown, one intriguing hypothesis is that migraineurs are genetically...

    Authors: Andrea M Harriott, Nicole Dueker, Yu-Ching Cheng, Kathleen A Ryan, Jeffrey R O’Connell, O Colin Stine, Patrick F McArdle, Marcella A Wozniak, Barney J Stern, Braxton D Mitchell, Steven J Kittner and John W Cole

    Citation: SpringerPlus 2013 2:46

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  30. Content type: Case study

    We report two patients who developed a prolonged featureless headache, they think after a drink was ‘spiked’. We speculate that each was exposed to scopolamine, resulting in enhanced trigeminal release of vaso...

    Authors: Richard Peatfield and Carlos M Villalón

    Citation: SpringerPlus 2013 2:39

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  31. Content type: Case study

    Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described, e.g. tumours, particularly pituitary adenomas, malf...

    Authors: Bengt Edvardsson and Staffan Persson

    Citation: SpringerPlus 2013 2:4

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  32. Content type: Letter to the Editor

    We conducted a descriptive study of children presenting with recurrent headaches to the general pediatric services of a tertiary-care, public hospital in northern India. This paper reports on the triggering fa...

    Authors: Devendra Mishra and Ankit Sharma

    Citation: SpringerPlus 2012 1:45

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