Skip to main content


Imaging and dosimetry for radionuclide based therapy

EJNMMI Physics welcomes submissions on imaging and dosimetry for radionuclide-based therapy. Radionuclide therapy and molecular radiotherapy are established modalities for the treatment of certain cancer types. In recent years there has been a significant expansion of new therapy options, radiopharmaceuticals and applications. Dosimetry is an essential component in the treatment chain to maximize the delivered absorbed dose to cancerous tissue while minimizing the dose to healthy organs. 

To highlight the rapid changes in this field and to address the remaining challenges, EJNMMI Physics is publishing an article collection on this topic. For this collection, we invite contributions on the many different aspects of imaging and dosimetry of radionuclides for therapeutic use. 

This collection will describe recent advances in the field and the manuscripts can be state-of-the-art review papers or original research papers. These papers can have a multi-disciplinary approach but the primary focus should be on medical physics or engineering related aspects.

Guest Editors
Hugo De Jong, University of Utrecht, Utrecht, Netherlands
Yuni Dewaraja, University of Michigan Medical School, Ann Arbor, United States
Gerhard Glatting, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Michael Ljungberg, Lund University, Lund, Sweden

For editorial enquiries please contact

  1. Content type: Original research

    The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney abso...

    Authors: Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J. Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman and Jeremy Godefroy

    Citation: EJNMMI Physics 2018 5:36

    Published on:

  2. Content type: Original research

    Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

    Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler

    Citation: EJNMMI Physics 2018 5:30

    Published on:

  3. Content type: Original research

    Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

    Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2018 5:28

    Published on:

  4. Content type: Original research

    The purpose was to validate 90Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

    Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja

    Citation: EJNMMI Physics 2018 5:31

    Published on:

  5. Content type: Review

    Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles...

    Authors: Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2018 5:22

    Published on:

  6. Content type: Original research

    Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...

    Authors: Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2018 5:25

    Published on:

  7. Content type: Original research

    This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177Lu) in current clinical practice. Our aim was to assess the feasibility of using i...

    Authors: Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping and Andrew Nisbet

    Citation: EJNMMI Physics 2018 5:17

    Published on:

  8. Content type: Original research

    Peptide receptor radionuclide therapy (PRRT) with [177Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the ...

    Authors: Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

    Citation: EJNMMI Physics 2018 5:10

    Published on:

  9. Content type: Original research

    SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration prot...

    Authors: Adrien Halty, Jean-Noël Badel, Olga Kochebina and David Sarrut

    Citation: EJNMMI Physics 2018 5:11

    Published on:

  10. Content type: Original research

    Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom ge...

    Authors: Wei Zhao, Pedro L. Esquinas, Xinchi Hou, Carlos F. Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K. Dewaraja and Anna Celler

    Citation: EJNMMI Physics 2018 5:8

    Published on:

  11. Content type: Original research

    Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using 111In-octreotide or by PET/CT imaging using 68Ga-radiolabelled somatostatin analogs. These imaging techniques will...

    Authors: L. Jönsson, A. Stenvall, E. Mattsson, E. Larsson, A. Sundlöv, T. Ohlsson and C. Hindorf

    Citation: EJNMMI Physics 2018 5:5

    Published on:

  12. Content type: Original research

    The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photo...

    Authors: Carlos F. Uribe, Pedro L. Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay and Anna Celler

    Citation: EJNMMI Physics 2018 5:2

    Published on:

  13. Content type: Original research

    The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

    Authors: Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe…

    Citation: EJNMMI Physics 2017 4:27

    Published on:

  14. Content type: Original research

    In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liv...

    Authors: Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali and Andrea Schenk

    Citation: EJNMMI Physics 2017 4:25

    Published on: