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Organoids as Models for Development (or Cell Fate Determination) and Diseases

Leading editors:
Dr. Ye-Guang Chen (School of Life Sciences, Tsinghua University, China)
Dr. Lijian Hui (CAS Center for Excellence in Molecular Cell Science, China)

A thematic series in Cell Regeneration.

Organoids are cultured cellular structures that consist of the major cell types of a tissue including tissue stem cells and other differentiated cells, resemble the basic features and possess the functions of the tissue. They can be derived directly from isolated organs or differentiated from embryonic stem cells or induced pluripotent stem cells. Therefore, organoids are great models for investigation of organ formation and regeneration, organ homeostasis, human development and disease mechanisms as well as for drug discovery and sensitivity test, having great potentials in personalized medicine. 

To highlight recent progress on organoids research, Cell Regeneration is inviting submissions to its upcoming special issue on “Organoids as models for development (or cell fate determination) and diseases”.

We will especially welcome Research, Method and Review submissions, including (but not limited to) the following areas:

  • Novel organoid culture methods
  • Organoids to assess developmental processes and tissue homeostasis
  • Organoids and tissue complexity
  • Polarity and maturation in organoids
  • Inherited and acquired diseases using organoid models
  • Cancer organoids
  • Organoids and personalized medicine
  • 3D printing of tissues and their utilization
  • Microfluidic devices and stem cell-derived tissues

The Editor-in-Chief of Cell Regeneration will review all submissions prior to peer review and may reject any of them that do not fit the scope of the journal or do not meet the journal's standards for peer review. All articles of Thematic Series will undergo full, independent peer review, in line with the journal's ethical and editorial policies, outlined in its submission guidelines. There is no guarantee of acceptance, even for commissioned or invited papers. The journal’s Editor-in-Chief has a final authority on editorial content.

  1. Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver organoid (HLO) derived from human pluripotent stem cells offers...

    Authors: Xiaoshan Wu, Dacheng Jiang, Yi Yang, Shuang Li and Qiurong Ding
    Citation: Cell Regeneration 2023 12:6
    Content type: Report Published on:

  2. Early human brain development can be affected by multiple prenatal factors that involve chemical exposures in utero, maternal health characteristics such as psychiatric disorders, and cancer. Breast cancer is one...

    Authors: Kangli Cui, Wenwen Chen, Rongkai Cao, Yingying Xie, Peng Wang, Yunsong Wu, Yaqing Wang and Jianhua Qin
    Citation: Cell Regeneration 2022 11:7
    Content type: Report Published on:

  3. Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs. The difficulty might be largely attributed ...

    Authors: Ting Li, Yejun Zou, Shuning Liu, Yi Yang, Zhuo Zhang and Yuzheng Zhao
    Citation: Cell Regeneration 2022 11:5
    Content type: Review Published on:

  4. Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility. Human pluripotent stem cells (hPSCs)-derived brain organ...

    Authors: Xiaoxiang Lu, Jiajie Yang and Yangfei Xiang
    Citation: Cell Regeneration 2022 11:1
    Content type: Review Published on:

  6. The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. With a ...

    Authors: Xiao Zhang, Wen Wang and Zi-Bing Jin
    Citation: Cell Regeneration 2021 10:33
    Content type: Review Published on:

  7. Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses. Organoids have been shown to be promising models for dru...

    Authors: Haonan Li, Yalong Wang, Mengxian Zhang, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji and Ye-Guang Chen
    Citation: Cell Regeneration 2021 10:32
    Content type: Methodology Published on:

  10. Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an...

    Authors: Do Thuy Uyen Ha Lam, Yock Young Dan, Yun-Shen Chan and Huck-Hui Ng
    Citation: Cell Regeneration 2021 10:27
    Content type: Review Published on:

  11. Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, ...

    Authors: Tiantian Lu, Yiyuan Cao, Peng Zhao, Shengxi Shen and Ying Xi
    Citation: Cell Regeneration 2021 10:21
    Content type: Review Published on:

  12. Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem ce...

    Authors: Yaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng and Guoqiang Hua
    Citation: Cell Regeneration 2020 9:21
    Content type: Review Published on:

  13. Apparent Young’s modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization...

    Authors: Anqi Guo, Bingjie Wang, Cheng Lyu, Wenjing Li, Yaozu Wu, Lu Zhu, Ran Bi, Chenyu Huang, Jiao Jiao Li and Yanan Du
    Citation: Cell Regeneration 2020 9:15
    Content type: Research Published on: