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Organ Regeneration in Model Organisms

Leading Editor: Jingwei Xiong, Jinrong Peng and Lingfei Luo
A thematic series in Cell Regeneration.


In the last decade, while the tremendous scientific advance in stem cells and tissue engineering for regenerative biology and medicine, it remains challenged to translate such findings into clinics. Alternatively, some vertebrate animals such as zebrafish and frogs have great potential of whole-organ regeneration after injury, therefore understanding regenerative mechanisms in these animals may lead to revealing new therapeutic prevention and intervention in the field of regenerative medicine. To highlight these progresses on organ regeneration in model organisms, Cell Regeneration is currently inviting submissions to its upcoming special issue on Organ Regeneration in Model Organisms. 

  1. Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineering field have resulted in mechanical support and biological substitutes to restore, maintai...

    Authors: Nicole Andréa Corbellini Henckes, Dalana Faleiro, Laura Chao Chuang and Elizabeth Obino Cirne-Lima
    Citation: Cell Regeneration 2021 10:26
  2. Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of pro...

    Authors: Zhaohui Ouyang and Ke Wei
    Citation: Cell Regeneration 2021 10:14
  3. Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investi...

    Authors: Hanqian Xu, Hailin Zhang, Yanqing Fang, Huiran Yang, Ying Chen, Chao Zhang and Gufa Lin
    Citation: Cell Regeneration 2021 10:19
  4. Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mo...

    Authors: Lixia Zheng, Jianyong Du, Zihao Wang, Qinchao Zhou, Xiaojun Zhu and Jing-Wei Xiong
    Citation: Cell Regeneration 2021 10:13
  5. The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining...

    Authors: Kaimeng Niu, Hao Xu, Yuanyi Zhou Xiong, Yun Zhao, Chong Gao, Chris W. Seidel, Xue Pan, Yuqing Ying and Kai Lei
    Citation: Cell Regeneration 2021 10:15
  6. The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis, whereas nuclear accumulation of β-catenin requires the activation of Rac1, a member of the Rho small GTPase family...

    Authors: Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng and Ximei Wu
    Citation: Cell Regeneration 2021 10:8
  7. As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the deta...

    Authors: Yicong Ma, Jing Xie, Chandra Sugiarto Wijaya and Suhong Xu
    Citation: Cell Regeneration 2021 10:5
  8. The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells (ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells i...

    Authors: Guoli Zhu, Jiulong Hu and Rongwen Xi
    Citation: Cell Regeneration 2021 10:1
  9. Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte poly...

    Authors: Jing-Wei Xiong
    Citation: Cell Regeneration 2020 9:23
  10. The pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Althoug...

    Authors: Bingyuan Yang, Brittney A. Covington and Wenbiao Chen
    Citation: Cell Regeneration 2020 9:9
  11. Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy (PH) is a prerequisite for liver transplantation. Synchronized cell cycle reentry of the existing hepatocy...

    Authors: Feng Chen, Delai Huang, Hui Shi, Ce Gao, Yingchun Wang and Jinrong Peng
    Citation: Cell Regeneration 2020 9:8