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Stem Cell Differentiation, Transdifferentiation, and Reprogramming

Leading Editors:
Prof. Guanghui Liu (Institute of Zoology, Chinese Academy of Sciences, China)
Prof. Ye-Guang Chen (School of Life Sciences, Tsinghua University, China)

A thematic series in Cell Regeneration.

Stem cells harbor the potentials of self-renewal and differentiation towards a variety of somatic cells, providing translational possibilities for regenerative medicine. Meanwhile, transdifferentiation between distinct cell types and reprogramming of somatic cells to induced pluripotent stem cells can obtain multiple types of stem cell models, facilitating the study of life sciences and biomedicine. Therefore, a better understanding of stem cell development and cell fate decision will provide insights for investigating materials and strategies for regenerative medicine.  

To advance basic biological research and translational medicine application on stem cells, Cell Regeneration is inviting submissions to its upcoming special issue on “Stem Cell Differentiation, Transdifferentiation, and Reprogramming”.

We encourage original Research, Method, and Review submissions, including (but not limited to) the following areas:

  • Molecular mechanisms and novel approaches in stem cell differentiation, transdifferentiation, and reprogramming
  • Stem cell homeostasis and function
  • Stem cell-derived organoids
  • Disease modeling and drug discovery
  • Stem cell-based interventions, therapies, and ethical considerations

The Editor-in-Chief of Cell Regeneration will review all submissions prior to peer review and may reject any of them that do not fit the scope of the journal or do not meet the journal's standards for peer review. All articles of Thematic Series will undergo full, independent peer review, in line with the journal's ethical and editorial policies, outlined in its submission guidelines. There is no guarantee of acceptance, even for commissioned or invited papers. The journal’s Editor-in-Chief has a final authority on editorial content.

  1. Asymmetric division is a fundamental process for generating cell diversity and maintaining the stem cell population. During asymmetric division, proteins, organelles, and even RNA are distributed unequally bet...

    Authors: Shanshan Chao, Huiwen Yan and Pengcheng Bu
    Citation: Cell Regeneration 2024 13:5
  2. High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research. However, simultaneous detection of activated core factors responsible for cell ...

    Authors: Jun Li, Jun Chi, Yang Yang, Zhongya Song, Yong Yang, Xin Zhou, Yang Liu and Yang Zhao
    Citation: Cell Regeneration 2023 12:22
  3. Adipose tissues are essential for actively regulating systemic energy balance, glucose homeostasis, immune responses, reproduction, and longevity. Adipocytes maintain dynamic metabolic needs and possess hetero...

    Authors: Jiayin Ye, Cheng Gao, Yong Liang, Zongliu Hou, Yufang Shi and Ying Wang
    Citation: Cell Regeneration 2023 12:13

    The Correction to this article has been published in Cell Regeneration 2023 12:20

  4. Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating ...

    Authors: Xiaoru Ling, Xinyi Liu, Shaoshuai Jiang, Lili Fan and Junjun Ding
    Citation: Cell Regeneration 2022 11:42
  5. The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we ...

    Authors: Shixin Gong, Gongcheng Hu, Rong Guo, Jie Zhang, Yiqi Yang, Binrui Ji, Gang Li and Hongjie Yao
    Citation: Cell Regeneration 2022 11:34
  6. Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using...

    Authors: Deepti Abbey
    Citation: Cell Regeneration 2022 11:27
  7. Mouse embryonic stem cells (mESCs) cycle in and out of a transient 2-cell (2C)-like totipotent state, driven by a complex genetic circuit involves both the coding and repetitive sections of the genome. While a...

    Authors: Lu Li, Pishun Li, Jiale Chen, Li Li, Yunfan Shen, Yangzixuan Zhu, Jiayi Liu, Lu Lv, Song Mao, Fang Chen, Guang Hu and Kai Yuan
    Citation: Cell Regeneration 2022 11:25
  8. Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic...

    Authors: Wenwen Jin and Wei Jiang
    Citation: Cell Regeneration 2022 11:24

    The Correction to this article has been published in Cell Regeneration 2022 11:30

  9. Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential. The main reason is that malignant glioma holds key cluster cells, glioma stem cells (GSCs). GSCs contr...

    Authors: Xin-Xin Han, Shengkai Jin, Li-Ming Yu, Min Wang, Xin-Yu Hu, Dai-Yu Hu, Jie Ren, Meng-Han Zhang, Wei Huang, Jia-Jia Deng, Qing-Qing Chen, Zhengliang Gao, Hua He and Chunhui Cai
    Citation: Cell Regeneration 2022 11:23