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Advanced targeted imaging and therapy in precision oncology: A multidisciplinary challenge

  1. The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FD...

    Authors: Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante and Arturo Chiti
    Citation: EJNMMI Research 2023 13:54
    Content type: Short communication Published on:

  2. Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in n...

    Authors: Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson and Christine Spitzweg
    Citation: EJNMMI Research 2022 12:25
    Content type: Review Published on:

  3. Hyperpolarization enhances the sensitivity of nuclear magnetic resonance experiments by between four and five orders of magnitude. Several hyperpolarized sensor molecules have been introduced that enable high ...

    Authors: Wai-Yan Ryana Fok, Martin Grashei, Jason G. Skinner, Bjoern H. Menze and Franz Schilling
    Citation: EJNMMI Research 2022 12:24
    Content type: Original research Published on:

  4. In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...

    Authors: Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger, Angela M. Krackhardt and Calogero D’Alessandria
    Citation: EJNMMI Research 2022 12:5
    Content type: Review Published on:

  5. Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients.

    Authors: Volker Morath, Michael Heider, Markus Mittelhäuser, Hannes Rolbieski, Jacob Stroh, Jérémie Calais, Matthias Eiber, Florian Bassermann and Wolfgang A. Weber
    Citation: EJNMMI Research 2022 12:4
    Content type: Short communication Published on:

  6. Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. ...

    Authors: Sabrina Marcazzan, Marcos J. Braz Carvalho, Matthias Konrad, Julia Strangmann, Anna Tenditnaya, Theresa Baumeister, Roland M. Schmid, Hans-Jürgen Wester, Vasilis Ntziachristos, Dimitris Gorpas, Timothy C. Wang, Margret Schottelius and Michael Quante
    Citation: EJNMMI Research 2022 12:2
    Content type: Preliminary research Published on:

  7. Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure a...

    Authors: Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff and Tilo Biedermann
    Citation: EJNMMI Research 2021 11:127
    Content type: Review Published on:

  8. Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors...

    Authors: Na Sun, Marija Trajkovic-Arsic, Fengxia Li, Yin Wu, Corinna Münch, Thomas Kunzke, Annette Feuchtinger, Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Jens T. Siveke and Axel Walch
    Citation: EJNMMI Research 2021 11:120
    Content type: Original research Published on:

  9. The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary ...

    Authors: Martina Sollini, Francesco Bartoli, Lara Cavinato, Francesca Ieva, Alessandra Ragni, Andrea Marciano, Roberta Zanca, Luca Galli, Fabiola Paiar, Francesco Pasqualetti and Paola Anna Erba
    Citation: EJNMMI Research 2021 11:119
    Content type: Original research Published on:

  10. The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

    Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur
    Citation: EJNMMI Research 2021 11:104
    Content type: Review Published on:

  11. Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily imp...

    Authors: Jessie Han, Luke Harrison, Lisa Patzelt, Mingming Wu, Daniela Junker, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos
    Citation: EJNMMI Research 2021 11:94
    Content type: Review Published on:

  12. Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

    Authors: Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert and Katja Steiger
    Citation: EJNMMI Research 2021 11:83
    Content type: Short communication Published on:

  13. The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

    Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller
    Citation: EJNMMI Research 2021 11:77
    Content type: Original research Published on:

  14. The prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is incre...

    Authors: Hui Wang, Thomas Amiel, Christoph Würnschimmel, Thomas Langbein, Katja Steiger, Isabel Rauscher, Thomas Horn, Tobias Maurer, Wolfgang Weber, Hans-Juergen Wester, Karina Knorr and Matthias Eiber
    Citation: EJNMMI Research 2021 11:76
    Content type: Original research Published on:

  15. Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

    Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt
    Citation: EJNMMI Research 2021 11:72
    Content type: Original research Published on:

  16. In this prospective exploratory study, we evaluated the feasibility of [18F]fluorodeoxyglucose ([18F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

    Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…
    Citation: EJNMMI Research 2021 11:70
    Content type: Original research Published on: