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Advanced targeted imaging and therapy in precision oncology: A multidisciplinary challenge

  1. Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in n...

    Authors: Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson and Christine Spitzweg
    Citation: EJNMMI Research 2022 12:25
  2. Hyperpolarization enhances the sensitivity of nuclear magnetic resonance experiments by between four and five orders of magnitude. Several hyperpolarized sensor molecules have been introduced that enable high ...

    Authors: Wai-Yan Ryana Fok, Martin Grashei, Jason G. Skinner, Bjoern H. Menze and Franz Schilling
    Citation: EJNMMI Research 2022 12:24
  3. In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...

    Authors: Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger, Angela M. Krackhardt and Calogero D’Alessandria
    Citation: EJNMMI Research 2022 12:5
  4. Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients.

    Authors: Volker Morath, Michael Heider, Markus Mittelhäuser, Hannes Rolbieski, Jacob Stroh, Jérémie Calais, Matthias Eiber, Florian Bassermann and Wolfgang A. Weber
    Citation: EJNMMI Research 2022 12:4
  5. Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. ...

    Authors: Sabrina Marcazzan, Marcos J. Braz Carvalho, Matthias Konrad, Julia Strangmann, Anna Tenditnaya, Theresa Baumeister, Roland M. Schmid, Hans-Jürgen Wester, Vasilis Ntziachristos, Dimitris Gorpas, Timothy C. Wang, Margret Schottelius and Michael Quante
    Citation: EJNMMI Research 2022 12:2
  6. Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure a...

    Authors: Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff and Tilo Biedermann
    Citation: EJNMMI Research 2021 11:127
  7. Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors...

    Authors: Na Sun, Marija Trajkovic-Arsic, Fengxia Li, Yin Wu, Corinna Münch, Thomas Kunzke, Annette Feuchtinger, Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Jens T. Siveke and Axel Walch
    Citation: EJNMMI Research 2021 11:120
  8. The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary ...

    Authors: Martina Sollini, Francesco Bartoli, Lara Cavinato, Francesca Ieva, Alessandra Ragni, Andrea Marciano, Roberta Zanca, Luca Galli, Fabiola Paiar, Francesco Pasqualetti and Paola Anna Erba
    Citation: EJNMMI Research 2021 11:119
  9. The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

    Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller
    Citation: EJNMMI Research 2021 11:77
  10. Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

    Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt
    Citation: EJNMMI Research 2021 11:72
  11. In this prospective exploratory study, we evaluated the feasibility of [18F]fluorodeoxyglucose ([18F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

    Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…
    Citation: EJNMMI Research 2021 11:70