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Computational Systems Biology 2010

  1. In recent years, cell population models have become increasingly common. In contrast to classic single cell models, population models allow for the study of cell-to-cell variability, a crucial phenomenon in mo...

    Authors: Jan Hasenauer, Julian Heinrich, Malgorzata Doszczak, Peter Scheurich, Daniel Weiskopf and Frank Allgöwer
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:4
  2. The identification of molecular target and mechanism of action of compounds is a key hurdle in drug discovery. Multiplexed techniques for bead-based expression profiling allow the measurement of transcriptiona...

    Authors: Florian Nigsch, Janna Hutz, Ben Cornett, Douglas W Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro and Jeremy L Jenkins
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:2
  3. In systems biology, experimentally measured parameters are not always available, necessitating the use of computationally based parameter estimation. In order to rely on estimated parameters, it is critical to...

    Authors: Syed Murtuza Baker, C Hart Poskar and Björn H Junker
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:7
  4. Boolean models of regulatory networks are assumed to be tolerant to perturbations. That qualitatively implies that each function can only depend on a few nodes. Biologically motivated constraints further show ...

    Authors: Steffen Schober, David Kracht, Reinhard Heckel and Martin Bossert
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:6
  5. Proteins and their interactions are essential for the survival of each human cell. Knowledge of their tissue occurrence is important for understanding biological processes. Therefore, we analyzed microarray an...

    Authors: Dorothea Emig, Tim Kacprowski and Mario Albrecht
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:5
  6. Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFκB activation caused by continuous IKKβ phosphorylation. We have recently published a strictly reduced ordinary...

    Authors: Johannes Witt, Sandra Barisic, Oliver Sawodny, Michael Ederer, Dagmar Kulms and Thomas Sauter
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:3
  7. Plant carbohydrate metabolism comprises numerous metabolite interconversions, some of which form cycles of metabolite degradation and re-synthesis and are thus referred to as futile cycles. In this study, we p...

    Authors: Sebastian Henkel, Thomas Nägele, Imke Hörmiller, Thomas Sauter, Oliver Sawodny, Michael Ederer and Arnd G Heyer
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:2
  8. Elucidating the structure and/or dynamics of gene regulatory networks from experimental data is a major goal of systems biology. Stochastic models have the potential to absorb noise, account for un-certainty, ...

    Authors: Elena S Dimitrova, Indranil Mitra and Abdul Salam Jarrah
    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:1