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Biophysics and biomaterials

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Understanding biophysics has become a key part of research eventually leading to diagnostics and treatments. Similarly, biomaterials—both biomemetics and bio-compatible materials—are growing in importance.

SpringerOpen and BioMed Central publish a leading portfolio of open access journals on the forefront of this research. 

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New Content ItemNanostructured biomaterials

Journal: Biomaterials Research
Lead Guest Editor: Oh Hyeong Kwon, Kumoh National Institute of Technology, Korea
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New Content Item​​​​​​Smart biomaterials for translational nanomedicines

Journal: Biomaterials Research
Lead Guest Editor: Sei Kwang Hahn, Pohang University of Science and Technology (POSTECH), Korea

Article Highlights

New Content ItemCalcium phosphates and silicon: exploring methods of incorporation

...The incorporation/adsorption of Si into CaP coatings was successfully achieved and hMSCs responded with an increase in osteogenic genes expression with the increase of Si concentration. Furthermore, hMSCs cultured on CaP-I coatings expressed higher levels of ALP and OP, indicating that this may be the preferred method of incorporation of bioinorganics into CaPs...


Ana I. Rodrigues, Rui L. Reis, Clemens A. van Blitterswijk, Isabel B. Leonor and Pamela Habibović

Biomaterials Research


Article accesses: 39
Review
New Content ItemBiological mechanisms of gold nanoparticle radiosensitization

There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence in vitro supported by a limited amount of in vivo experiments, along with advances in mechanistic understanding, GNPs have not yet translated into the clinic. This may be due to disparity between predicted levels of radiosensitization based on physical action, observed biological response and an incomplete mechanistic understanding, alongside current experimental limitations. This paper provides a review of the current state of the field, highlighting the potential underlying biological mechanisms in GNP radiosensitization and examining the barriers to clinical translation.


Soraia Rosa, Chris Connolly, Giuseppe Schettino, Karl T. Butterworth, and Kevin M. Prise

Cancer Nanotechnology

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Altmetric score: 7
(9 tweets, 15 Mendeley)
Citations: 1
Article access: +600
New Content ItemImpact of superparamagnetic iron oxide nanoparticles on vocal fold fibroblasts: cell behavior and cellular iron kinetics
...To develop 3D structures, cell behavior should not be affected by SPION uptake. After 40 days, cells were free of iron as a result of metabolism or rarefication during cell division. Cell functions including adhesion, spreading, and migration were proven to be intact in a dose-dependent manner after SPION treatment, suggesting a safe usage of MTE for voice rehabilitation. Our results thus constitute a solid basis for a successful transfer of this technique into 3D constructs, in order to provide an individual and personalized human VF implant in the future...

Marina Pöttler, Anna Fliedner, Eveline Schreiber, Christina Janko, Ralf Philipp Friedrich, Christopher Bohr, Michael Döllinger, Christoph Alexiou, and Stephan Dürr


Nanoscale Research Letters

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Altmetric score: 1 
(1 tweet)
Article accesses: +39
New Content ItemRoll-designed 3D nanofibrous scaffold suitable for the regeneration of load bearing bone defects
In this work, an innovative and easy method for the fabrication of 3D scaffold from 2D electrospun structures is introduced. For this aim, coral microparticles were fixed inside the nanofibrous PCL/Gelatin mat and the obtained structure was post assembled into a cylindrical design. Scaffold fabrication procedure is described in detail and morphological properties, physical and mechanical characteristics and in vitro assessments of the prepared scaffold are reported. Presences of coral microparticles in the structure led to the formation of empty spaces (3D pores) between nanofibrous layers which in turn prevent the compact accumulation of nanofibers. Post-assembly of the obtained nanofibrous coral-loaded structures makes it possible to prepare a scaffold with any desired dimension (diameter and height). Existence of coral particles within the nanofibrous mats resulted in distant placement of layers toward each other in the assembling step, which in turn create vacancy in the structure for cellular migration and fluid and nutrients exchange of the scaffold with the surrounding environment...

Fatemeh Hejazi, Hamid Mirzadeh
Progress in Biomaterials
Article access: +380
New Content ItemFabrication approaches for the creation of physical models from microscopy data

Background

Three-dimensional (3D) printing has become a useful method of fabrication for many clinical applications. It is also a technique that is becoming increasingly accessible, as the price of the necessary tools and supplies decline. One emerging, and unreported, application for 3D printing is to aid in the visualization of 3D imaging data by creating physical models of select structures of interest...


Benjamin L. Cox, Nathan Schumacher, John Konieczny,

Issac Reifschneider, Thomas R. Mackie, Marisa S. Otegui, and Kevin W. Eliceiri


3D Printing in Medicine

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Altmetric score: 1
(1 tweet, 1 Facebook post, 2 Mendeley)
Article Accesses: +450

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New Content ItemKrasten Blagoev

Co-Editor-in-Chief of Cancer Convergence

Open access allows worldwide communication between researchers and the public and I believe is part of the democratization of science.

​​​​​​​New Content ItemFred J. Currell and Stephen Curley

Editors-in-Chief of Cancer Nanotechnology

@CancerNanotech

We are convinced that through nanotechnology-based investigations involving basic underpinning principles from physics and chemistry we have an opportunity to enhance our understanding of malignant diseases.

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