- Ethics and consent
- Access to publications
- Research involving human embryos, gametes, and stem cells
- Sex and gender in research (SAGER)
- Research involving animals
- Research involving plants
- Research involving palaeontological and geological material
- Dual Use Research of Concern
- Standards for research in complementary and alternative medicine
- Consent for publication
- Trial registration
- Availability of data and materials
- Standards of reporting
- Describing new taxa
- Competing interests
- Artificial Intelligence (AI)
- Duplicate publication
- Text recycling
- Peer review
- Corrections and retractions
- Appeals and complaints
Table of contents
OverviewBack to top
SpringerOpen, as part of SpringerNature, is a member of the Committee on Publication Ethics (COPE) and endorses the World Association of Medical Editors (WAME) Policy Statement on Geopolitical Intrusion on Editorial Decisions. SpringerOpen also endorses the International Committee of Medical Journal Editors (ICMJE) Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals. Submission of a manuscript to a SpringerOpen journal implies that all authors have read and agreed to its content and that the manuscript conforms to the journal’s policies. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Ethics and consentBack to top
Research involving human participants, human material, or human data, must have been performed in accordance with the Declaration of Helsinki and must have been approved by an appropriate ethics committee. A statement detailing this, including the name of the ethics committee and the reference number where appropriate, must appear in all manuscripts reporting such research. If a study has been granted an exemption from requiring ethics approval, this should also be detailed in the manuscript (including the name of the ethics committee that granted the exemption). Further information and documentation to support this should be made available to the Editor on request. Manuscripts may be rejected if the Editor considers that the research has not been carried out within an appropriate ethical framework. In rare cases, the Editor may contact the ethics committee for further information.
Retrospective ethics approval
If a study has not been granted ethics committee approval prior to commencing, retrospective ethics approval usually cannot be obtained and it may not be possible to consider the manuscript for peer review. The decision on whether to proceed to peer review in such cases is at the Editor's discretion.
New clinical tools and procedures
Authors reporting the use of a new procedure or tool in a clinical setting, for example as a technical advance or case report, must give a clear justification in the manuscript for why the new procedure or tool was deemed more appropriate than usual clinical practice to meet the patient’s clinical need. Such justification is not required if the new procedure is already approved for clinical use at the authors’ institution. Authors will be expected to have obtained ethics committee approval and informed patient consent for any experimental use of a novel procedure or tool where a clear clinical advantage based on clinical need was not apparent before treatment.
Consent to participate
For all research involving human participants, informed consent to participate in the study should be obtained from participants (or their parent or legal guardian in the case of children under 16) and a statement to this effect should appear in the manuscript. For manuscripts reporting studies involving vulnerable groups (for example, unconscious patients) where there is the potential for coercion (for example prisoners) or where consent may not have been fully informed, manuscripts will be considered at the editor’s discretion and may be referred to an internal editorial oversight group for further scrutiny. Consent must be obtained for all forms of personally identifiable data including biomedical, clinical, and biometric data. In the case of articles describing human transplantation studies, authors must include a statement declaring that no organs/tissues were obtained from prisoners and must also name the institution(s)/clinic(s)/department(s) via which organs/tissues were obtained. Documentary evidence of consent must be supplied if requested.
Access to publicationsBack to top
All SpringerOpen publications are open access
Every article appearing in any SpringerOpen journal and any book published with SpringerOpen is 'open access', meaning that:
- The article/book is universally and freely accessible via the Internet, in an easily readable format. All publications are deposited immediately upon publication, without embargo, in an agreed format - current preference is XML with a declared DTD - in at least one widely and internationally recognized open access repository.
- The author(s) or copyright owner(s) irrevocably grant(s) to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article/book in its entirety or in part, in any format or medium, provided that no substantive errors are introduced in the process, proper attribution of authorship and correct citation details are given, and that the bibliographic details are not changed. If the article/book is reproduced or disseminated in part, this must be clearly and unequivocally indicated.
Springer is committed permanently to maintaining this open access publishing policy, retrospectively and prospectively, in all eventualities, including any future changes in ownership.
Research involving human embryos, gametes, and stem cellsBack to top
Manuscripts that report experiments involving the use of human embryos and gametes, human embryonic stem cells and related materials, and clinical applications of stem cells must include confirmation that all experiments were performed in accordance with relevant guidelines and regulations (See also Ethics and Consent)
The manuscript should include an ethics statement identifying the institutional and/or national research ethics committee (including the name of the ethics committee) approving the experiments and describing any relevant details. Authors should confirm that informed consent (See also Ethics and Consent and Consent for publication) was obtained from all recipients and/or donors of cells or tissues, where necessary, and describe the conditions of donation of materials for research, such as human embryos or gametes. Copies of approval and redacted consent documents may be requested by the Editor.
We encourage authors to follow the principles laid out in the ISSCR Guidelines for Stem Cell Research and Clinical Translation.
In deciding whether to publish papers describing modifications of the human germline, the Editors are guided by safety considerations, compliance with applicable regulations, as well as the status of the societal debate on the implications of such modifications for future generations. In case of concerns regarding a particular type of study the Editor may seek advice from the Springer Nature Research Integrity Group.
The decision to publish a paper is the responsibility of the Editor-in-Chief of the Journal.
Sex and gender in research (SAGER)Back to top
We encourage our authors to follow the ‘Sex and Gender Equity in Research – SAGER – guidelines’ and to include sex and gender considerations where relevant. Authors should use the terms sex (biological attribute) and gender (shaped by social and cultural circumstances) carefully in order to avoid confusing both terms. Article titles and/or abstracts should indicate clearly what sex(es) the study applies to. Authors should also describe in the background, whether sex and/or gender differences may be expected; report how sex and/or gender were accounted for in the design of the study; provide disaggregated data by sex and/or gender, where appropriate; and discuss respective results. If a sex and/or gender analysis was not conducted, the rationale should be given in the Discussion. We suggest that our authors consult the full guidelines before submission.
- Definition of Sex and Gender (taken from Office of Research in Women’s Health, NIH).
- Sex - refers to biological differences between females and males, including chromosomes, sex organs, and endogenous hormonal profiles.
- Gender- refers to socially constructed and enacted roles and behaviors which occur in a historical and cultural context and vary across societies and over time.
- Applications of the guidelines: These guidelines apply to studies involving humans, vertebrate animal and cell lines.
Research involving animalsBack to top
Experimental research on vertebrates or any regulated invertebrates must comply with institutional, national, or international guidelines, and where available should have been approved by an appropriate ethics committee. The Basel Declaration outlines fundamental principles to adhere to when conducting research in animals and the International Council for Laboratory Animal Science (ICLAS) has also published ethical guidelines.
A statement detailing compliance with relevant guidelines (e.g. the revised Animals (Scientific Procedures) Act 1986 in the UK and Directive 2010/63/EU in Europe) and/or ethical approval (including the name of the ethics committee and the reference number where appropriate) must be included in the manuscript. If a study has been granted an exemption from requiring ethics approval, this should also be detailed in the manuscript (including the name of the ethics committee that granted the exemption and the reasons for the exemption). The Editor will take account of animal welfare issues and reserves the right to reject a manuscript, especially if the research involves protocols that are inconsistent with commonly accepted norms of animal research. In rare cases, the Editor may contact the ethics committee for further information.
For experimental studies involving client-owned animals, authors must also document informed consent from the client or owner and adherence to a high standard (best practice) of veterinary care.
Field studies and other non-experimental research on animals must comply with institutional, national, or international guidelines, and where available should have been approved by an appropriate ethics committee. A statement detailing compliance with relevant guidelines and/or appropriate permissions or licences must be included in the manuscript. We recommend that authors comply with the IUCN Policy Statement on Research Involving Species at Risk of Extinction and the Convention on the Trade in Endangered Species of Wild Fauna and Flora.
Research involving plantsBack to top
Experimental research and field studies on plants (either cultivated or wild), including the collection of plant material, must comply with relevant institutional, national, and international guidelines and legislation.
Manuscripts should include a statement specifying the appropriate permissions and/or licences for collection of plant or seed specimens. We recommend that authors comply with the IUCN Policy Statement on Research Involving Species at Risk of Extinction and the Convention on the Trade in Endangered Species of Wild Fauna and Flora.
To support reproducibility, voucher specimens for all wild plants described in a manuscript must be deposited in a public herbarium or other public collection that provides access to deposited material. Information on the voucher specimen and who identified it must be included in the manuscript.
Research involving palaeontological and geological material
Details of palaeontological specimens and geological samples should include clear provenance information to ensure full transparency of the research.
It is recognized that precise provenance information may not be available for older museum collections. In circumstances where providing specific provenance information may compromise the security of palaeontological or geological sites it may be appropriate to exclude detailed locality information.
Samples must always be collected and exported in a responsible manner and in accordance with applicable local and national laws. Any submission detailing new material should include information regarding the requisite permissions obtained and the issuing authority. Authors may be required to provide specific supporting documentation upon request.
Type, figured and cited palaeontological specimens, should be deposited in a recognised museum or collection to permit free access by other researchers in perpetuity. Sufficient information on the repository, including the assigned unique catalogue numbers (where applicable), should be provided to allow the specimens to be traced.
We encourage deposition of 3-D scans of fossil specimens (where appropriate) within a permanent, accessible repository to facilitate study by the scientific community.
Springer Nature requires that submitted content adheres to the United Nations Educational, Scientific and Cultural Organization (UNESCO) normative instruments for the protection of cultural heritage, and Resolutions, Motions, guidance and other statements of the International Union for the Conservation of Nature (IUCN).
Dual Use Research of Concern
Some manuscripts provide information that could be directly misapplied to pose a significant threat to public health, safety or security, agricultural crops and other plants, animals, or the environment. For such information to be published, the benefit to the research community, society, or to public health, must outweigh any risks. We reserve the right to take expert advice in cases where we believe that concerns may arise, and we may require a manuscript to undergo peer review specifically to assess the dual use risk. Where the risk of misuse outweighs any potential benefit, publication is declined; published content may be corrected, retracted or removed.
Researchers are expected to comply with their institutional and funder’s requirements, as well as any national regulations. They should be aware of dual-use concerns related to their work and take steps to minimize misuse of their research. Such concerns include, but are not limited to, biosecurity, nuclear and chemical threats. Where relevant regulations exist, authors should disclose whether their study is subject to consideration as dual use research of concern; if it is, the manuscript should report the authority granting approval and reference number for the regulatory approval. When the study reports material that can be harmful outside the laboratory context, the manuscript should describe appropriate containment (e.g. biosafety) procedures.
We recognize the widespread view that openness in science helps to alert society to potential threats and to defend against them, and we anticipate that only very rarely will the risks be perceived as outweighing the benefits of publishing a paper that has otherwise been deemed appropriate for publication.
Standards for research in complementary and alternative medicineBack to top
Springer Nature journals are committed to evidence-based research. We believe that Complementary and Alternative Medicine (CAM) research should be held to the same standards and evidence threshold as those of medicine research.
We welcome manuscripts for submission which meet the following clinical research standards:
- Clinical research manuscripts that comply with international and national standards for such work (such as the Declaration of Helsinki or relevant Governmental regulation e.g. the UK’s The Medicines for Human Use (Clinical Trials) Regulations).
- Studies which are adequately controlled (be that compared to a placebo or conventional medicine), blinded (where appropriate), randomised and of sufficient statistical power to confidentially and accurately interpret the effect reported. Studies reporting a CAM treatment/technique compared only to another CAM treatment/technique are not sufficient to test the efficacy of the CAM treatment in question. Studies in which a conventional treatment is supplemented with a CAM technique are only valid if compared to the same conventional treatment supplemented with a placebo.
- CAM treatments/techniques tested on animal models and/or human patients: It is unethical for such work, on humans or animals, to have taken place without adequate prior evidence that the treatment/technique shows some potential of being therapeutic. Manuscripts must include evidence that takes the form of objective, measurable data from previously published peer reviewed literature which adheres to scientific principles (for instance in vitro or cellular work). Other forms of evidence are not valid. Manuscripts describing work lacking this evidence will not be considered on ethical grounds.
Consent for publicationBack to top
For all manuscripts that include details, images, or videos relating to an individual person, written informed consent for the publication of these details must be obtained from that person (or their parent or legal guardian in the case of children under 18). The consent must be for publication of their details under the Creative Commons Attribution License 4.0 (such that they will be freely available on the internet). If the person has died, consent for publication must be obtained from their next of kin. The manuscript must include a statement that written informed consent for publication was obtained.
Authors can use the consent form to obtain consent for publication, or a consent form from their own institution or region if appropriate. The consent form must state that the details/images/videos will be freely available on the internet and may be seen by the general public. The consent form must be made available to the Editor if requested, and will be treated confidentially.
In cases where images are entirely unidentifiable and there are no details on individuals reported within the manuscript, consent for publication of images may not be required. The final decision on whether consent to publish is required lies with the Editor.
Trial registrationBack to top
SpringerOpen, as part of SpringerNature, supports initiatives to improve reporting of clinical trials. This includes prospective registering of clinical trials in suitable publicly available databases. In line with ICMJE guidelines, SpringerOpen requires registration of all clinical trials that are reported in manuscripts submitted to its journals.
The ICMJE uses the World Health Organization (WHO) definition of a clinical trial, which is "any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes". This definition includes phase I to IV trials. The ICMJE defines health-related interventions as "any intervention used to modify a biomedical or health-related outcome" and health-related outcomes as "any biomedical or health-related measures obtained in patients or participants". Authors who are unsure whether their trial needs registering should consult the ICMJE FAQs for further information.
Suitable publicly available registries are those listed on the ICMJE website as well as any of the primary registries that participate in the WHO International Clinical Trials Registry Platform, including the ISRCTN registry, which is administered and published by SpringerOpen.
The trial registration number (TRN) and date of registration should be included as the last line of the manuscript abstract.
Publication of study protocols reduces the risk of non-publication of research findings and facilitates methodological discussion, and is encouraged by a number of SpringerOpen journals. If the study protocol for a trial has been published, then it should be cited in the manuscript.
For clinical trials that have not been registered prospectively, SpringerOpen encourages retrospective registration to ensure the complete publication of all results. Further information on retrospective registration is available from the AllTrials campaign, the Public Accounts Committee and the Department of Health.
Many journals published by SpringerOpen will consider manuscripts describing retrospectively registered studies. The TRN, date of registration and the words 'retrospectively registered’ should be included as the last line of the manuscript abstract.
Registration of systematic reviews
SpringerOpen journals support the prospective registration of systematic reviews and encourages authors to register their systematic reviews in a suitable registry (such as PROSPERO). Authors who have registered their systematic review should include the registration number as the last line of the manuscript abstract.
Availability of data and materialsBack to top
Submission of a manuscript to a SpringerOpen journal implies that materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for non-commercial purposes, without breaching participant confidentiality.
For all journals, SpringerOpen strongly encourages that all datasets on which the conclusions of the paper rely should be available to readers, and where there is a community established norm for data sharing, SpringerOpen mandates data deposition (for data types with required deposition, see below).
We encourage authors to ensure that their datasets are either deposited in publicly available repositories (where available and appropriate) or presented in the main manuscript or additional supporting files, in machine-readable format (such as spreadsheets rather than PDFs) whenever possible. Please see the list of recommended repositories. For several journals, deposition of the data on which the conclusions of the manuscript rely is required. Please check the individual journal’s Submission Guidelines for more information.
Authors who need help understanding our data sharing policies, finding a suitable data repository, or organising and sharing research data can access our Author Support portal for additional guidance.
Availability of data and materials section
All authors must include an “Availability of Data and Materials” section in their manuscript detailing where the data supporting their findings can be found. Authors who do not wish to share their data must state that data will not be shared, and give the reason.
Availability of data and materials statements can take one of the following forms (or a combination of more than one if required for multiple datasets):
- The datasets generated and/or analysed during the current study are available in the [NAME] repository, [PERSISTENT WEB LINK TO DATASETS]
- The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
- All data generated or analysed during this study are included in this published article [and its supplementary information files].
- The datasets generated and/or analysed during the current study are not publicly available due [REASON WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on reasonable request.
- Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.
- The data that support the findings of this study are available from [third party name] but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of [third party name].
- Not applicable. If your manuscript does not contain any data, please state 'Not applicable' in this section.
SpringerOpen endorses the Force 11 Data Citation Principles and requires that all publicly available datasets be fully referenced in the reference list with an accession number or unique identifier such as a digital object identifier (DOI).
List of recommended repositories
A list of recommended repositories by subject area and data type can be found on the Springer Nature Recommended Repositories list.
Community-established norm of data deposition
DNA and RNA sequences
DNA and RNA sequencing data
Linked genotype and phenotype data
Worldwide Protein Data Bank (wwPDB)
Microarray data (must be MIAME compliant)
Crystallographic data for small molecules
Publication of clinical datasets
For datasets containing clinical data, authors have an ethical and legal responsibility to respect participants’ rights to privacy and to protect their identity. Ideally, authors should gain informed consent for publication of the dataset from participants at the point of recruitment to the trial. If this is not possible, authors must demonstrate that publication of such data does not compromise anonymity or confidentiality or breach local data protection laws, for the dataset to be considered for publication. Authors must consider whether the dataset contains any direct or indirect identifiers (see here for further information) and consult their local ethics committee or another appropriate body before submission if there is any possibility that participants will not be fully anonymous. Authors must state in their manuscript on submission whether informed consent was obtained for publication of patient data. If informed consent was not obtained, authors must state the reason for this, and which body was consulted in the preparation of the dataset.
Software and code
Any previously unreported software application or custom code described in the manuscript should be available for testing by reviewers in a way that preserves their anonymity. The manuscript should include a description in the Availability of Data and Materials section of how the reviewers can access the unreported software application or custom code. This section should include a link to the most recent version of your software or code (e.g. GitHub or Sourceforge) as well as a link to the archived version referenced in the manuscript. The software or code should be archived in an appropriate repository with a DOI or other unique identifier. For software in GitHub, we recommend using Zenodo. If published, the software application/tool should be readily available to any scientist wishing to use it for non-commercial purposes, without restrictions (such as the need for a material transfer agreement). If the implementation is not made freely available, then the manuscript should focus clearly on the development of the underlying method and not discuss the tool in any detail.
Standards of reportingBack to top
SpringerOpen advocates complete and transparent reporting of biomedical and biological research. For biomedical and biological research, the checklist below must be completed before peer review, and made available to the Editors and reviewers.
- Randomized controlled trials (CONSORT)
We strongly recommend that authors refer to the minimum reporting guidelines for health research hosted by the EQUATOR Network when preparing their manuscript, and FAIRsharing.org for reporting checklists for biological and biomedical research, where applicable.
In addition, SpringerOpen strongly encourage the use of the following checklists and reporting guidelines:
- Protocols for randomized controlled protocols (SPIRIT)
- Systematic reviews and meta-analyses* (PRISMA) and protocols (PRISMA-P)
- Observational studies (STROBE)
- Case reports (CARE)
- Qualitative research (COREQ)
- Diagnostic/prognostic studies (STARD and TRIPOD)
- Economic evaluations (CHEERS)
- Pre-clinical animal studies (ARRIVE)
- Statistics checklists for editors and reviewers to use when evaluating the statistics in manuscripts:
In addition, journals may mandate that other reporting guidelines are followed and the exact requirements may vary depending on the journal; please refer to the journal’s submission guidelines.
Authors should include full information on the statistical methods and measures used in their research, including justification of the appropriateness of the statistical test used (see the SAMPL guidelines for more information). Reviewers will be asked to check the statistical methods, and the manuscript may be sent for specialist statistical review if considered necessary.
To enable effective tracking of the key resources used to produce the scientific findings reported in the biomedical literature, authors are expected to include a full description of all resources with enough information to allow them to be uniquely identified. In support of the Resource Identification Initiative (RII), we encourage authors to use unique Resource Identifiers (RRIDs) within their manuscript to identify their model organisms, antibodies, or tools.
Cell line authentication
If human cell lines are used, authors are strongly encouraged to include the following information in their manuscript:
- The source of the cell line, including when and from where it was obtained
- Whether the cell line has recently been authenticated and by what method
- Whether the cell line has recently been tested for mycoplasma contamination
Further information is available from the International Cell Line Authentication Committee (ICLAC). We recommend that authors check the NCBI database for misidentification and contamination of human cell lines.
Standardized gene nomenclature should be used throughout. Human gene symbols and names can be found in the HUGO Gene Nomenclature Committee (HGNC) database; requests for new gene symbols should be submitted here and any enquiries about gene nomenclature can be directed here. Alternative gene aliases that are commonly used may also be reported, but should not be used alone in place of the HGNC symbol. Nomenclature committees for other species are listed here.
Reporting of sequence variants
We endorse the recommendations of the Human Variome Project Consortium for describing sequence variants (Human Genome Variation Society) and phenotypes (Human Phenotype Ontology).
We recommend that authors should submit all variants described in a manuscript to the relevant public gene/disease specific database (LSDB): a list is available here. The database URL and the unique identifier should be reported in the manuscript.
To drive the maximum re-use and utility of published research, we expect authors to comply with available field-specific standards for the preparation and recording of data. Please see the FairSharing website for information on field-specific data standards. Authors must comply with best practice in their field for sharing of data, with particular attention to maintaining patient confidentiality.
Authors using unpublished genomic data are expected to abide by the guidelines of the Fort Lauderdale and Toronto agreements. Based on broadly accepted scientific community standards, the key requirement of third parties using genomic data is to contact the owners of unpublished data (i.e. the principal investigator and sequencing centre) prior to undertaking their research, to advise them about their planned analyses.
Digital image integrity
Adapted from the Journal of Cell Biology and from Nature Research.
While a certain degree of image processing is unavoidable for some experiments, fields and techniques, in all instances, the final image presented in the published article must accurately represent the original data and conform to community standards. The guidelines on image processing presented below will aid in accurate data presentation; authors must also take care to exercise caution during data acquisition to avoid misrepresentation of the data collected.
Authors should list all image acquisition tools and image processing software packages used, noting the specific version of the software. If the data were processed with custom code, this should be fully described and deposited into a community repository. All image-gathering settings and processing manipulations should be fully described in the methods.
When preparing figures for publication, adhere to the following guidelines:
- Images gathered at different times or from different locations should not be combined into a single image, unless it is stated that the resultant image is a product of time-averaged data or a time-lapse sequence. If juxtaposing images is essential, the borders should be clearly demarcated in the figure and described in the legend.
- Touch-up tools, such as cloning and healing tools in Photoshop, or any feature that deliberately obscures manipulations, should not be used.
- Processing (such as changing brightness and contrast) is appropriate only when it is applied equally across the entire image and is applied equally to controls. Contrast should not be adjusted so that data disappear. Excessive manipulations, such as processing to emphasize one region in the image at the expense of others (e.g. through the use of a biased choice of threshold settings), are inappropriate, as is emphasizing experimental data relative to the control.
- Authors should be prepared to submit original, unprocessed images on request.
Electrophoretic gels and blots
The display of cropped gels and blots in the main paper is allowed if it improves the clarity and conciseness of the presentation. In such cases, the cropping must be mentioned in the figure legend. For some SpringerOpen journals, the inclusion of the original, uncropped gel or blot is mandatory and the full length original blot or gel should be included in the additional files.
- Quantitative comparisons between samples on different gels/blots are discouraged; if this is unavoidable, the figure legend must state that the samples derive from the same experiment and that gels/blots were processed in parallel. Vertically sliced images that juxtapose lanes that were non-adjacent in the gel must have a clear separation or a black line delineating the boundary between the gels. Loading controls must be run on the same blot.
- Cropped gels in the paper must retain important bands.
- High-contrast gels and blots are discouraged, as overexposure may mask additional bands. Authors should strive for exposures with gray backgrounds. Multiple exposures should be presented in Supplementary Information if high contrast is unavoidable. Immunoblots should be surrounded by a black line to indicate the borders of the blot, if the background is faint.
- For quantitative comparisons, appropriate reagents, controls and imaging methods with linear signal ranges should be used.
Authors should be prepared to supply the journal with original data on request, at the resolution collected, from which their images were generated. Cells from multiple fields should not be juxtaposed in a single field; instead multiple supporting fields of cells should be shown as Supplementary Information.
- Adjustments should be applied to the entire image. Threshold manipulation, expansion or contraction of signal ranges and the altering of high signals should be avoided. If 'pseudo-colouring' and nonlinear adjustment (e.g. 'gamma changes') are used, this must be disclosed. Adjustments of individual colour channels are sometimes necessary on 'merged' images, but this should be noted in the figure legend.
- In the methods, specify the type of equipment (microscopes/objective lenses, cameras, detectors, filter model and batch number) and acquisition software used. Although we appreciate that there is some variation between instruments, equipment settings for critical measurements should also be listed. In addition, processing software should be named and manipulations indicated (such as type of deconvolution, three-dimensional reconstructions, surface and volume rendering, 'gamma changes', filtering, thresholding and projection).
- Authors should state the measured resolution at which an image was acquired and any downstream processing or averaging that enhances the resolution of the image.
Describing new taxaBack to top
Algal, fungal, and botanical names
Since January 2012, the electronic publication of algal, fungal, and botanical names has been a valid form of publication. Manuscripts containing new taxon names or other nomenclatural acts must follow the guidelines set by the International Code of Nomenclature for algae, fungi, and plants. Further helpful information by Sandra Knapp et al. is available here.
Authors describing new fungal taxa should register the names with a recognized repository, such as Mycobank, and request a unique digital identifier which should be included in the published article.
Since January 2012, electronic publication of zoological names has been a valid form of publication if certain conditions are met. Manuscripts containing new taxon names or other nomenclatural acts must follow the guidelines set by the International Commission on Zoological Nomenclature. We require the new taxon name and the article it is published in to be registered with ZooBank. The unique identifier provided by ZooBank should be included in the published article. Authors will be able to update ZooBank with the final citation following publication. Further helpful information by Frank-T. Krell is available here.
In accordance with the International Code of Nomenclature of Prokaryotes (ICNP) effective publication of new prokaryotic names in electronic journals is possible. In order to comply with rules of the International Committee on Systematics of Prokaryotes (ICSP) for valid publication authors must submit a copy of the published article in its final form, together with certificates of deposition of the type strain (for unrestricted distribution), in at least two internationally recognized, publicly accessible culture collections located in different countries, to the International Journal of Systematic and Evolutionary Microbiology (IJSEM) editorial office. Following review by the List Editor, effectively published names that conform to all of the rules of the ICNP will appear on a subsequent Validation List, in the order received, thereby becoming validly published.
The proposal of new virus names must follow the guidelines established by the International Committee on Taxonomy of Viruses (ICTV) in the International Code of Virus Classification and Nomenclature. Proposals for new virus taxa should be forwarded to the relevant Study Group of the ICTV for consideration.
Competing interestsBack to top
SpringerOpen requires authors to declare all competing interests in relation to their work. All submitted manuscripts must include a ‘competing interests’ section at the end of the manuscript listing all competing interests (financial and non-financial). Where authors have no competing interests, the statement should read “The author(s) declare(s) that they have no competing interests”. The Editor may ask for further information relating to competing interests.
Editors and reviewers are also required to declare any competing interests and will be excluded from the peer review process if a competing interest exists.
What constitutes a competing interest?
Competing interests may be financial or non-financial. A competing interest exists when the authors’ interpretation of data or presentation of information may be influenced by their personal or financial relationship with other people or organizations. Authors should disclose any financial competing interests but also any non-financial competing interests that may cause them embarrassment if they were to become public after the publication of the manuscript.
Financial competing interests
Financial competing interests include (but are not limited to):
- Receiving reimbursements, fees, funding, or salary from an organization that may in any way gain or lose financially from the publication of the manuscript, either now or in the future
- Holding stocks or shares in an organization that may in any way gain or lose financially from the publication of the manuscript, either now or in the future
- Holding, or currently applying for, patents relating to the content of the manuscript
- Receiving reimbursements, fees, funding, or salary from an organization that holds or has applied for patents relating to the content of the manuscript
Non-financial competing interests
Non-financial competing interests include (but are not limited to) political, personal, religious, ideological, academic, and intellectual competing interests. If, after reading these guidelines, you are unsure whether you have a competing interest, please contact firstname.lastname@example.org.
Authors from pharmaceutical companies, or other commercial organizations that sponsor clinical trials, should declare these as competing interests on submission. They should also adhere to the Good Publication Practice guidelines for pharmaceutical companies (GPP2), which are designed to ensure that publications are produced in a responsible and ethical manner. The guidelines also apply to any companies or individuals that work on industry-sponsored publications, such as freelance writers, contract research organizations and communications companies. SpringerOpen journals will not publish advertorial content.
Editorial Board Members and Editors
Editorial Board Members and Editors are required to declare any competing interests and may be excluded from the peer review process if a competing interest exists.
In addition, they should exclude themselves from handling manuscripts in cases where there is a competing interest. This may include – but is not limited to – having previously published with one or more of the authors, and sharing the same institution as one or more of the authors.
Where an Editor or Editorial Board Member is on the author list they must declare this in the competing interests section on the submitted manuscript. If they are an author or have any other competing interest regarding a specific manuscript, another Editor or member of the Editorial Board will be assigned to assume responsibility for overseeing peer review. These submissions are subject to the exact same review process as any other manuscript.
Editorial Board Members are welcome to submit papers to the journal. These submissions are not given any priority over other manuscripts, and Editorial Board Member status has no bearing on editorial consideration.
All Springer Nature journal editorial staff are required to declare to their employer any interests — financial or otherwise — that might influence, or be perceived to influence, their editorial practices. Failure to do so is a disciplinary offence. Springer Nature has a strict policy of editorial independence in individual acceptance decisions and editorial standards of quality and significance should never be compromised. While some editors are financially incentivised to achieve journal growth, we are clear in our internal policies and individuals’ contracts or formal objectives that this should be achieved by ensuring submissions of sufficient quality and never by compromising editorial standards.
Artificial Intelligence (AI)Back to top
Large Language Models (LLMs), such as ChatGPT, do not currently satisfy our authorship criteria. Notably an attribution of authorship carries with it accountability for the work, which cannot be effectively applied to LLMs. Use of an LLM should be properly documented in the Methods section (and if a Methods section is not available, in a suitable alternative part) of the manuscript.
Generative AI Images
The fast moving area of generative AI image creation has resulted in novel legal copyright and research integrity issues. As publishers, we strictly follow existing copyright law and best practices regarding publication ethics. While legal issues relating to AI-generated images and videos remain broadly unresolved, Springer Nature journals are unable to permit its use for publication.
Exceptions are images/art obtained from agencies that we have contractual relationships with that have created images in a legally acceptable manner. Other exceptions to this policy include images and video that are directly referenced in a piece that is specifically about AI and will be reviewed on a case-by-case basis.
As we expect things to develop rapidly in this field in the near future, we will review this policy regularly and adapt it if necessary.
Please note: Not all AI tools are generative. The use of non-generative machine learning tools to manipulate, combine or enhance existing images or figures should be disclosed in the relevant caption upon submission to allow a case-by-case review.
CitationsBack to top
Research articles and non-research articles (e.g. Opinion, Review, and Commentary articles) must cite appropriate and relevant literature in support of the claims made. Excessive self-citation, coordinated efforts among several authors to collectively self-cite, gratuitous and unnecessary citation of articles published in the journal to which the paper has been submitted, and any other form of citation manipulation are inappropriate.
Citation manipulation will result in the article being rejected, and may be reported to authors’ institutions. Similarly, any attempts by peer-reviewers or editors to encourage such practices should be reported by authors to the publisher.
- Authors should consider the following guidelines when preparing their manuscript:
- Any statement in the manuscript that relies on external sources of information (i.e. not the authors' own new ideas or findings or general knowledge) should use a citation.
- Authors should avoid citing derivations of original work. For example, they should cite the original work rather than a review article that cites an original work.
- Authors should ensure that their citations are accurate (i.e. they should ensure the citation supports the statement made in their manuscript and should not misrepresent another work by citing it if it does not support the point the authors wish to make).
- Authors should not cite sources that they have not read.
- Authors should not preferentially cite their own or their friends’, peers’, or institution’s publications.
- Authors should avoid citing work solely from one country.
- Authors should not use an excessive number of citations to support one point.
- Ideally, authors should cite sources that have undergone peer review where possible.
- Authors should not cite advertisements or advertorial material.
Duplicate publicationBack to top
Any manuscript submitted to a SpringerOpen journal must be original and the manuscript, or substantial parts of it, must not be under consideration by any other journal. In any case where there is the potential for overlap or duplication we require that authors are transparent. Authors should declare any potentially overlapping publications on submission and, where possible, upload these as additional files with the manuscript. Any overlapping publications should be cited. Any ‘in press’ or unpublished manuscript cited, or relevant to the Editor’s and reviewers' assessment of the manuscript, should be made available if requested by the Editor. SpringerOpen journals reserve the right to judge potentially overlapping or redundant publications on a case-by-case basis.
In general, the manuscript should not already have been formally published in any journal or in any other citable form. If justified and made clear upon submission, there are exceptions to this rule. Details of these exceptions follow below and are also summarized in [Table 1].
SpringerOpen, as part of SpringerNature, is a member of CrossCheck’s plagiarism detection initiative and takes seriously all cases of publication misconduct. Any suspected cases of covert duplicate manuscript submission will be handled as outlined in the COPE guidelines and the Editor may contact the authors’ institution (see Misconduct policy for more information). SpringerOpen endorses the policies of the ICMJE in relation to overlapping publications.
Cochrane systematic reviews
SpringerOpen does not currently have a co-publication agreement with the Cochrane Library for its systematic reviews. SpringerOpen will therefore only consider publishing novel Cochrane systematic reviews, or updated versions of articles in the Cochrane Library if they provide substantial new information.
Co-publication in multiple journals
If transparent, and with prior agreement of the relevant journals and under the conditions specified in the ICMJE guidelines, co-publication in multiple journals will be considered at the Editor's discretion.
Health technology assessment
The reports of the NHS Health Technology Assessment (HTA) programme are freely accessible in full online. At the Editor's discretion, some SpringerOpen journals will consider full or shortened versions of these articles for peer review.
Preprint servers and author/institutional repositories
Posting a manuscript on a preprint server or an author's personal or institutional website does not constitute previous publication. Please see our preprint sharing and citation policy for further information.
SpringerOpen encourages self-archiving by authors of manuscripts accepted for publication in its journals.
SpringerOpen will consider submissions containing material that has previously formed part of a PhD or other academic thesis including those that have been made publicly available according to the requirements of the institution awarding the qualification.
Translations into English
Authors should comply with the ICMJE guidelines and seek approval from the original publisher to check that they do not breach the copyright terms of the original publication and that the original publisher gives permission for publication of the translation under the Creative Commons Attribution License 4.0.
At the Editor's discretion, some SpringerOpen journals will consider manuscripts that are substantially extended versions of articles that have previously been published in another peer-reviewed journal. In such cases the prior publication of an abridged version of the article would therefore not preclude publication, provided the new manuscript represents a substantially novel contribution to the scientific record. If applicable, the authors should seek approval from the original publisher before submitting the extended version of the manuscript.
Prior abstracts of up to 400 words and posters presented at, or published as part of, academic meetings do not preclude consideration for peer review of a full manuscript, as the full manuscript represents a formal advance to the citable scientific record. Published abstracts should be cited. Authors should be aware that many conference proceedings exceed the allowable word limit and constitute a citable form.
Making scientific data sets publicly available before associated manuscripts are submitted will not preclude consideration by a SpringerOpen journal. Because an increasing number of research funding agencies require that their grant holders share the 'raw data' research outputs, such data sharing is encouraged by SpringerOpen, provided appropriate safeguards are in place to protect personal or sensitive information.
Authors of non-research articles (usually commissioned reviews and commentaries) can include figures and tables that have been previously published in other journals provided they confirm on submission that permission has been obtained from the original publisher (if applicable) and cite the original article. Documentary evidence to support this permission must be made available to the Editor on request.
In order to avoid the potential for self-plagiarism, inadvertently or otherwise, authors agreeing to write commissioned articles should notify the Editor of any recent publications or invitations to write on a similar topic.
If authors have previously discussed or posted their own data in venues such as blogs, wikis, social networking websites, or online electronic lab notebooks, they are still able to submit their findings to SpringerOpen journals. However, given the rapidly evolving nature of these resources, where discussion of data or manuscripts posted to these venues has subsequently been incorporated into the manuscript, the Editor will make their own assessment as to whether there may be duplication in the submitted manuscript.
Publication of study protocols reduces the risk of non-publication of research findings and facilitates methodological discussion, and is encouraged by a number of SpringerOpen journals. Therefore prior publication of a study protocol before submission of a manuscript reporting the results is not considered duplicate publication.
Summary clinical trial results in public registries
Posting of summary clinical trial results in publicly accessible databases is generally not considered duplicate publication. SpringerOpen requires authors of manuscripts reporting clinical trials to have registered their trial in a suitably accessible registry (see our Trial Registration policy for more information). In the US, submission of trial results to ClinicalTrials.gov is a statutory requirement. More information on this requirement can be found here.
Table 1. Generally permissible and non-permissible forms of duplicate/overlapping publication
Guidance on permissibility
At the Editor's discretion, provided there is agreement from the original journal/publisher and the original publication is cited
Abstracts up to 400 words or posters presented at scientific meetings
Yes - published abstracts should be cited
Co-publication in multiple journals
At the Editor's discretion
Datasets in public or restricted access repositories
Yes - datasets should be cited in/hyperlinked from the manuscript if possible
Figures and tables in non-research articles
Yes, if, where applicable, permission has been obtained from the original publisher by the submitting author
Open science: data posted and discussed on wikis, blogs, online electronic lab notebooks, networking websites incorporated into submitted manuscript
Yes, usually permissible
Preprint servers, including authors' personal and institutional websites
Yes – this does not constitute previous publication
Study protocol published
Yes - published protocols should be cited
Summary results in clinical trial registries
Yes - accession number should be included in the abstract
At the Editor's discretion, provided there is agreement from the original journal/publisher, no breach of copyright and the original publication is cited.
Text recyclingBack to top
Authors should be aware that replication of text from their own previous publications is text recycling (also referred to as self-plagiarism), and in some cases is considered unacceptable. Where overlap of text with authors’ own previous publications is necessary or unavoidable, duplication must always be reported transparently and be properly attributed and compliant with copyright requirements. In line with COPE, SpringerOpen has created guidelines for Editors on how to deal with text recycling which provide further detailed information on when text recycling is or is not considered acceptable. If a manuscript contains text that has been published elsewhere, authors should notify the Editor of this on submission.
Peer reviewBack to top
All research articles, and most other article types, published in SpringerOpen journals undergo thorough peer review. This usually involves review by two independent peer reviewers. Individual journals may differ in their peer review processes; for example, some journals operate an open and others a closed peer review system. For an individual journal’s peer review policy, please see the journal's 'About' page.
Peer review policy
All submissions to SpringerOpen journals are assessed by an Editor, who will decide whether they are suitable for peer review. Where an Editor is on the author list or has any other competing interest regarding a specific manuscript, another member of the Editorial Board will be assigned to assume responsibility for overseeing peer review. Submissions felt to be suitable for consideration will be sent for peer review by appropriate independent experts identified by the Handling Editor. Editors will make a decision based on the reviewers’ reports and authors are sent these reports along with the editorial decision on their manuscript. Authors should note that even in light of one positive report, concerns raised by another reviewer may fundamentally undermine the study and result in the manuscript being rejected.
Open peer review
For journals operating an open peer review process, the reviewers' names are included on the peer review reports. In addition, if the manuscript is published, the named reports are published online alongside the article. Previous versions of the manuscript may be available to readers on request by contacting email@example.com. On rare occasions, information from the pre-publication history may not be available for a specific article.
Closed peer review
Most journals operate a closed peer review process. Reviewers will be treated anonymously and the pre-publication history of each article will not be made available online.
Authors may suggest potential reviewers if they wish; however, whether or not to consider these reviewers is at the Editor's discretion. Authors should not suggest recent collaborators or colleagues who work in the same institution as themselves. Authors who wish to suggest peer reviewers can do so in the cover letter and should provide institutional email addresses where possible, or information which will help the Editor to verify the identity of the reviewer (for example an ORCID or Scopus ID).
Authors may request exclusion of individuals as peer reviewers, but they should explain the reasons in their cover letter on submission. Authors should not exclude too many individuals as this may hinder the peer review process. Please note that the Editor may choose to invite excluded peer reviewers.
Intentionally falsifying information, for example, suggesting reviewers with a false name or email address, will result in rejection of the manuscript and may lead to further investigation in line with our misconduct policy.
Portability of peer review
Within SpringerOpen journals
To support efficient and thorough peer review, we aim to reduce the number of times a manuscript is re-reviewed after rejection from a [SpringerOpen journal], thereby speeding up the publication process and reducing the burden on peer reviewers. If a manuscript does not reach the interest criteria of a given [SpringerOpen journal], but is sound and in scope for another SpringerOpen or SpringerNature journal, we offer authors the option to transfer the manuscript together with the reviewer reports to the other journal.
Editors may share manuscripts with Editors of other SpringerOpen or SpringerNature journals before contacting authors in order to assess suitability for transfer to another journal. Authors who do not wish their manuscript to be shared with other SpringerOpen or SpringerNature journals should indicate this in their cover letter on submission. Reviewers who do not wish us to share their report with another SpringerOpen or SpringerNature journal should indicate this in the confidential section of their report. Transfer of a manuscript does not imply that it will be automatically accepted by the receiving journal, and on some occasions the Editor of the receiving journal may need to conduct their own peer review and/or reject the manuscript if it is not suitable.
If a manuscript is transferred to, and published in, a journal with open peer review, we will, wherever possible, make the reviewers' reports available through the pre-publication history of the article (see ‘Open peer review’ above). On some occasions this will not be possible; for example, when the manuscript has been peer reviewed in a closed peer review journal first. Although we will ask reviewers to make their reports available, reviewers providing reports for closed peer review journals will sometimes prefer to maintain this confidentiality and their anonymity. In such cases we will publish a note from the Editor on the pre-publication history of the manuscript to explain the peer review history for that particular case.
Where a manuscript was initially reviewed in an open peer review journal and is subsequently transferred to a closed peer review journal and published, the reviews will not be published alongside the article.
Between SpringerOpen and other publishers/third parties
SpringerOpen supports innovations in peer review which can improve efficiency and save peer reviewers’ time and effort. Some SpringerOpen journals will consider manuscripts from other publishers, for example, journals in the Neuroscience Peer Review Consortium and from journals in the eLife consortium. We are also willing to consider manuscripts which have been reviewed by third parties. However, submission of a manuscript with reviewer reports from another journal or an independent review service does not imply that it will be automatically accepted by the receiving journal and additional peer review may be required
ConfidentialityBack to top
Editors will treat all manuscripts submitted to all SpringerOpen journals in confidence. SpringerOpen adheres to COPE’s Ethical Guidelines for Peer Reviewers. Reviewers are therefore required to respect the confidentiality of the peer review process and not reveal any details of a manuscript or its review, during or after the peer-review process, beyond the information released by the journal. If reviewers wish to involve a colleague in the review process they should first obtain permission from the journal. The Editor should be informed of the names of any individuals who assisted in the review process when the report is returned.
SpringerOpen will not share manuscripts with third parties outside of SpringerOpen except in cases of suspected misconduct. See our Misconduct policy for further information. Manuscripts may be shared with other Editors at SpringerOpen, unless authors indicate on submission that they do not wish for their manuscript to be passed on beyond the journal they submitted to. See portability of peer review for more information.
SpringerOpen regularly undertakes research projects designed to help improve processes for authors, reviewers and editors, and how science is communicated in our journals. Participation in this research will not affect the editorial review of manuscripts, the consideration given to reviewer reports by Editors or the confidentiality of the submission and review process. Depending on the nature of the research project we may seek ethical approval and may need to contact you for consent to participate. Research may be undertaken retrospectively after the publication of manuscripts; in all cases, details of manuscripts will be kept confidential.
MisconductBack to top
SpringerOpen takes seriously all allegations of potential misconduct. As members of COPE, all SpringerNature journals will follow the COPE guidelines outlining how to deal with cases of suspected misconduct.
In cases of suspected research or publication misconduct, it may be necessary for the Editor to contact and share manuscripts with third parties, for example, author(s)’ institution(s) and ethics committee(s). SpringerOpen may also seek advice from COPE and discuss anonymized cases in the COPE Forum. The editor may also involve SpringerOpen’s independent ombudsman.
All research involving humans (including human data and human material) and animals must have been carried out within an appropriate ethical framework (see our [Ethics] policy for further information). If there is suspicion that research has not taken place within an appropriate ethical framework, the Editor may reject a manuscript and may inform third parties, for example, author(s)’ institution(s) and ethics committee(s).
In cases of proven research misconduct involving published articles, or where the scientific integrity of the article is significantly undermined, articles may be retracted. See our Retraction policy for further information.
Data falsification and fabrication
Data falsification is manipulating research data with the intention of giving a false impression. This includes manipulating images, removing outliers or “inconvenient” results, changing, adding or omitting data points, etc. Data fabrication means the making up of research findings.
Any questions regarding data integrity raised during or after the peer review process will be referred to the Editor. The Editor may request (anonymised) underlying study data from the author(s) for inspection or verification. If the original data cannot be produced, the manuscript may be rejected or, in the case of a published article, retracted. Cases of suspected misconduct will be reported to the author(s)’ institution(s).
As members of COPE, all SpringerOpen journals will follow the COPE guidelines outlining how to deal with cases of potential publication misconduct.
SpringerOpen as part of SpringerNature is a member of CrossCheck’s plagiarism detection initiative and uses plagiarism detection software. If plagiarism is identified, the COPE guidelines on plagiarism will be followed. We follow COPE's definition of plagiarism.
Corrections and retractionsBack to top
Rarely, it may be necessary for SpringerOpen to publish corrections to, or retractions of, articles published in its journals, so as to maintain the integrity of the academic record.
In line with SpringerOpen’s Permanency policy, corrections to, or retractions of, published articles will be made by publishing a Correction or a Retraction note bidirectionally linked to the original article. Any alterations to the original article will be described in the note. The original article remains in the public domain and the subsequent Correction or Retraction will be widely indexed. In the exceptional event that material is considered to infringe certain rights or is defamatory, we may have to remove that material from our site and archive sites.
Authors, readers or organizations who become aware of errors or ethics issues in a published article are encouraged to contact the individual journal in the first instance via the contact details available on the journal website. All reports will be considered by the Editors; additional expert advice may be sought when deciding on the most appropriate course of action. The Springer Nature Research Integrity Group provides support to Editors in addressing publication ethics issues in a COPE (Committee on Publication Ethics)-compliant manner.
Changes to published articles that affect the interpretation and conclusion of the article, but do not fully invalidate the article, will, at the Editor(s)’ discretion, be corrected via publication of a Correction that is indexed and bidirectionally linked to the original article.
On rare occasions, when the interpretation or conclusion of an article is substantially undermined, it may be necessary for published articles to be retracted. SpringerOpen as part of SpringerNature will follow the COPE guidelines in such cases. Retraction notices are indexed and bidirectionally linked to the original article. The original article is watermarked as retracted and the title is amended with the prefix “Retracted article:”
Editorial Expressions of Concern
When an Editor becomes aware of serious concerns regarding interpretation or conclusion of a published article, they may choose to publish a statement alerting the readership. Scenarios in which Editorial Expressions of Concern may be published include prolonged investigations of very complex cases and when the concerns may have a significant and immediate impact on public health or public policy. An Editorial Expression of Concern may be superseded by a subsequent Correction or Retraction, but will remain part of the permanent published record.
Removal of published content
In exceptional circumstances, Springer Nature reserves the right to remove an article, chapter, book or other content from Springer Nature’s online platforms. Such action may be taken when (i) Springer Nature has been advised that content is defamatory, infringes a third party’s intellectual property right, right to privacy, or other legal right, or is otherwise unlawful; (ii) a court or government order has been issued, or is likely to be issued, requiring removal of such content; (iii) content, if acted upon, would pose an immediate and serious risk to health. Removal may be temporary or permanent. Bibliographic metadata (e.g. title and authors) will be retained, and will be accompanied by a statement explaining why the content has been removed.
Appeals and complaintsBack to top
Authors who wish to appeal a rejection or make a complaint should follow the procedure outlined in the BMC Editorial Policies.